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Cancers (neoplastic Diseases)

Explore Genetic Insights

Summary

Diseases Found 46
High Risk 1
Medium Risk 43
Low Risk 2
Mutated Genes Found 21

Contents

Cancers (Neoplastic Diseases)

The following diseases are associated with Cancers (Neoplastic Diseases):

Disease Predisposition
Genital Neoplasms, Male Medium
Prostatic Neoplasms Medium
Breast Neoplasms Medium
Gastrointestinal Neoplasms Medium
Digestive System Neoplasms Medium

Genital Neoplasms, Male

Meningeal neoplasms are a type of tumor that occurs in the meninges, which are the protective membranes covering the brain and spinal cord. These tumors can be benign (such as meningiomas) or malignant. As for genetic transmission, most meningeal neoplasms, particularly sporadic meningiomas, are not typically inherited. However, there are genetic syndromes, such as Neurofibromatosis Type 2 (NF2), that significantly increase the risk of developing these types of tumors. NF2 is an autosomal dominant disorder, meaning that a mutation in a single copy of the responsible gene (NF2 gene on chromosome 22) can cause the condition.

Predisposition: Medium
Explanation of predisposition: We predict genetic risk by analyzing specific genetic variants within key genes associated with a condition. For each variant, we assess its impact on biological pathways that are known to influence the disease. The prediction takes into account both the clinical significance of each variant and the confidence in the prediction, which is determined by the quality and strength of the supporting scientific data and research.
Associated Genes
Gene Mutation Type Allele Confidence
ZFYVE9 Duplication G/A Medium
ACAD9 Substitution T/A High
ZDHHC11 Duplication C/C High
MRPL36 Deletion T/G Medium
NQO2 Frameshift G/T Medium
Population Frequency By Gene

Population frequency indicates how common a specific genetic variant is within a group of people, expressed as a percentage. For example, if a gene variant has a frequency of 20%, it means about 20 out of 100 individuals carry that variant. This information helps researchers understand the potential impact of genetic variants on health and traits within different populations.

Gene Frequency
ZFYVE9 22%
ACAD9 22%
ZDHHC11 15%
MRPL36 25%
NQO2 25%
Associated Pathways

A pathway refers to a series of biochemical reactions and interactions that occur within cells, allowing for communication between genes, proteins, and metabolites. These pathways are crucial for various physiological functions, including neurotransmission, hormone signaling, and metabolic processes, and can influence behaviors and health outcomes when disrupted by genetic mutations.

Pathway Type Effects
REACT:R-HSA-6805567 Glutamatergic Transmission Plays a role in synaptic plasticity
Possible Comobordities

Comorbidities are additional health conditions that often occur alongside a primary condition. For example, someone with ADHD may also have other related issues, such as anxiety or learning difficulties. These conditions are linked because they may share similar causes, such as genetics or brain chemistry, making it more likely for a person to experience both at the same time.

Gene Comorbidities Associated Mechanism
ZFYVE9 Chronic Obstructive Pulmonary Disease (COPD) Mitochondrial impairment
ACAD9 Chronic Obstructive Pulmonary Disease (COPD) Mitochondrial impairment
ZDHHC11 Depression Inflammation
MRPL36 Osteoporosis Immune system dysfunction
NQO2 Coronary Artery Disease Genetic predisposition

Recommendations for Medium Risk for Meningeal Neoplasm

  • Consultation: Schedule a follow-up consultation with a primary care provider or genetic counselor.
  • Monitoring: Regularly monitor your health for early signs of the condition associated with your predisposition.
  • Lifestyle Adjustments: Implement moderate lifestyle changes to mitigate risk.
  • Personalized Lifestyle Plan:
    • Maintain a balanced diet rich in whole foods, lean protein, and healthy fats.
    • Engage in regular physical activity, such as walking, swimming, or light strength training.
    • Incorporate stress management techniques like deep breathing exercises or light yoga.
    • Limit alcohol consumption and reduce exposure to pollutants.

    For additional guidance on managing your predisposition: See treatment options for genital neoplasms, male.

Next Steps

Learn more about Meningeal Neoplasm.

See predicted treatments for genital neoplasms, male.

Schedule a consultation with a GeneHealth representative to discuss results.

Prostatic Neoplasms

Trophoblastic neoplasm is a type of gestational trophoblastic disease (GTD) that arises from abnormal growth of trophoblastic cells, which are cells that normally develop into the placenta during pregnancy. These neoplasms include conditions like hydatidiform mole, invasive mole, choriocarcinoma, and placental-site trophoblastic tumor. The type of genetic transmission for trophoblastic neoplasms is generally sporadic, meaning they are not inherited in a predictable pattern and typically occur due to genetic abnormalities during fertilization.

Predisposition: Medium
Explanation of predisposition: We predict genetic risk by analyzing specific genetic variants within key genes associated with a condition. For each variant, we assess its impact on biological pathways that are known to influence the disease. The prediction takes into account both the clinical significance of each variant and the confidence in the prediction, which is determined by the quality and strength of the supporting scientific data and research.
Associated Genes
Gene Mutation Type Allele Confidence
ZDHHC11 Inversion C/C High
TMEM45A Deletion A/C High
LRPPRC Inversion T/G Medium
ZFYVE9 Inversion G/G High
SLC12A7 Insertion T/G Medium
Population Frequency By Gene

Population frequency indicates how common a specific genetic variant is within a group of people, expressed as a percentage. For example, if a gene variant has a frequency of 20%, it means about 20 out of 100 individuals carry that variant. This information helps researchers understand the potential impact of genetic variants on health and traits within different populations.

Gene Frequency
ZDHHC11 6%
TMEM45A 23%
LRPPRC 13%
ZFYVE9 6%
SLC12A7 9%
Associated Pathways

A pathway refers to a series of biochemical reactions and interactions that occur within cells, allowing for communication between genes, proteins, and metabolites. These pathways are crucial for various physiological functions, including neurotransmission, hormone signaling, and metabolic processes, and can influence behaviors and health outcomes when disrupted by genetic mutations.

Pathway Type Effects
REACT:R-HSA-6805567 Hedgehog Signaling Pathway Regulates apoptosis and cell death
Possible Comobordities

Comorbidities are additional health conditions that often occur alongside a primary condition. For example, someone with ADHD may also have other related issues, such as anxiety or learning difficulties. These conditions are linked because they may share similar causes, such as genetics or brain chemistry, making it more likely for a person to experience both at the same time.

Gene Comorbidities Associated Mechanism
ZDHHC11 Asthma Immune system dysfunction
TMEM45A Hypertension Inflammation
LRPPRC Diabetes Chronic infection
ZFYVE9 Asthma Hormonal imbalance
SLC12A7 Depression Hormonal imbalance

Recommendations for Medium Risk for Trophoblastic Neoplasm

  • Consultation: Schedule a follow-up consultation with a primary care provider or genetic counselor.
  • Monitoring: Regularly monitor your health for early signs of the condition associated with your predisposition.
  • Lifestyle Adjustments: Implement moderate lifestyle changes to mitigate risk.
  • Personalized Lifestyle Plan:
    • Maintain a balanced diet rich in whole foods, lean protein, and healthy fats.
    • Engage in regular physical activity, such as walking, swimming, or light strength training.
    • Incorporate stress management techniques like deep breathing exercises or light yoga.
    • Limit alcohol consumption and reduce exposure to pollutants.

    For additional guidance on managing your predisposition: See treatment options for Prostatic Neoplasms.

Next Steps

Learn more about Trophoblastic Neoplasm.

See predicted treatments for Prostatic Neoplasms.

Schedule a consultation with a GeneHealth representative to discuss results.

Breast Neoplasms

Breast neoplasm, often referred to as breast cancer, primarily manifests in two forms: invasive and non-invasive. The type of genetic transmission associated with breast cancer can be hereditary or sporadic. Hereditary breast cancer often results from mutations in specific genes such as BRCA1 and BRCA2, which follow an autosomal dominant pattern of inheritance. This means a mutation in just one of the two copies of a gene is sufficient to increase the risk of developing the disease. Sporadic cases, which make up the majority, do not follow a specific pattern of inheritance and are typically attributed to genetic changes that occur by chance.

Predisposition: Medium
Explanation of predisposition: We predict genetic risk by analyzing specific genetic variants within key genes associated with a condition. For each variant, we assess its impact on biological pathways that are known to influence the disease. The prediction takes into account both the clinical significance of each variant and the confidence in the prediction, which is determined by the quality and strength of the supporting scientific data and research.
Associated Genes
Gene Mutation Type Allele Confidence
FAM110C Deletion A/G High
SDHA Frameshift A/A Medium
LRPPRC Duplication T/C High
ACAD9-DT Inversion C/A Medium
GRM6 Substitution T/T High
Population Frequency By Gene

Population frequency indicates how common a specific genetic variant is within a group of people, expressed as a percentage. For example, if a gene variant has a frequency of 20%, it means about 20 out of 100 individuals carry that variant. This information helps researchers understand the potential impact of genetic variants on health and traits within different populations.

Gene Frequency
FAM110C 2%
SDHA 20%
LRPPRC 12%
ACAD9-DT 18%
GRM6 15%
Associated Pathways

A pathway refers to a series of biochemical reactions and interactions that occur within cells, allowing for communication between genes, proteins, and metabolites. These pathways are crucial for various physiological functions, including neurotransmission, hormone signaling, and metabolic processes, and can influence behaviors and health outcomes when disrupted by genetic mutations.

Pathway Type Effects
REACT:R-HSA-74160 TGF-beta Signaling Pathway Critical for embryonic development
Possible Comobordities

Comorbidities are additional health conditions that often occur alongside a primary condition. For example, someone with ADHD may also have other related issues, such as anxiety or learning difficulties. These conditions are linked because they may share similar causes, such as genetics or brain chemistry, making it more likely for a person to experience both at the same time.

Gene Comorbidities Associated Mechanism
FAM110C Cancer Chronic infection
SDHA Coronary Artery Disease Immune system dysfunction
LRPPRC Coronary Artery Disease Inflammation
ACAD9-DT Hypertension Chronic infection
GRM6 Diabetes Inflammation

Recommendations for Medium Risk for Breast Neoplasm

  • Consultation: Schedule a follow-up consultation with a primary care provider or genetic counselor.
  • Monitoring: Regularly monitor your health for early signs of the condition associated with your predisposition.
  • Lifestyle Adjustments: Implement moderate lifestyle changes to mitigate risk.
  • Personalized Lifestyle Plan:
    • Maintain a balanced diet rich in whole foods, lean protein, and healthy fats.
    • Engage in regular physical activity, such as walking, swimming, or light strength training.
    • Incorporate stress management techniques like deep breathing exercises or light yoga.
    • Limit alcohol consumption and reduce exposure to pollutants.

    For additional guidance on managing your predisposition: See treatment options for Breast Neoplasms.

Next Steps

Learn more about Breast Neoplasm.

See predicted treatments for Breast Neoplasms.

Schedule a consultation with a GeneHealth representative to discuss results.

Gastrointestinal Neoplasms

Gastrointestinal anthrax is an infectious disease caused by the bacterium Bacillus anthracis. It is not genetically transmitted; rather, it is acquired through the ingestion of undercooked or contaminated meat from infected animals.

Predisposition: Medium
Explanation of predisposition: We predict genetic risk by analyzing specific genetic variants within key genes associated with a condition. For each variant, we assess its impact on biological pathways that are known to influence the disease. The prediction takes into account both the clinical significance of each variant and the confidence in the prediction, which is determined by the quality and strength of the supporting scientific data and research.
Associated Genes
Gene Mutation Type Allele Confidence
SDHA Inversion C/T High
MRPL36 Insertion T/A High
GSTM4 Deletion T/C Medium
MROH2B Duplication A/C Medium
ACAD9 Deletion C/G High
Population Frequency By Gene

Population frequency indicates how common a specific genetic variant is within a group of people, expressed as a percentage. For example, if a gene variant has a frequency of 20%, it means about 20 out of 100 individuals carry that variant. This information helps researchers understand the potential impact of genetic variants on health and traits within different populations.

Gene Frequency
SDHA 12%
MRPL36 13%
GSTM4 13%
MROH2B 9%
ACAD9 11%
Associated Pathways

A pathway refers to a series of biochemical reactions and interactions that occur within cells, allowing for communication between genes, proteins, and metabolites. These pathways are crucial for various physiological functions, including neurotransmission, hormone signaling, and metabolic processes, and can influence behaviors and health outcomes when disrupted by genetic mutations.

Pathway Type Effects
REACT:R-HSA-74160 Adrenergic Receptor Signaling Critical for embryonic development
Possible Comobordities

Comorbidities are additional health conditions that often occur alongside a primary condition. For example, someone with ADHD may also have other related issues, such as anxiety or learning difficulties. These conditions are linked because they may share similar causes, such as genetics or brain chemistry, making it more likely for a person to experience both at the same time.

Gene Comorbidities Associated Mechanism
SDHA Coronary Artery Disease Mitochondrial impairment
MRPL36 Parkinson's Disease Immune system dysfunction
GSTM4 Coronary Artery Disease Chronic infection
MROH2B Diabetes Cellular apoptosis
ACAD9 Hypertension Metabolic dysregulation

Recommendations for Medium Risk for Gastrointestinal Anthrax

  • Consultation: Schedule a follow-up consultation with a primary care provider or genetic counselor.
  • Monitoring: Regularly monitor your health for early signs of the condition associated with your predisposition.
  • Lifestyle Adjustments: Implement moderate lifestyle changes to mitigate risk.
  • Personalized Lifestyle Plan:
    • Maintain a balanced diet rich in whole foods, lean protein, and healthy fats.
    • Engage in regular physical activity, such as walking, swimming, or light strength training.
    • Incorporate stress management techniques like deep breathing exercises or light yoga.
    • Limit alcohol consumption and reduce exposure to pollutants.

    For additional guidance on managing your predisposition: See treatment options for Gastrointestinal Neoplasms.

Next Steps

Learn more about Gastrointestinal Anthrax.

See predicted treatments for Gastrointestinal Neoplasms.

Schedule a consultation with a GeneHealth representative to discuss results.

Digestive System Neoplasms

Connective tissue benign neoplasms typically include types such as lipomas, fibromas, hemangiomas, and neurofibromas. The genetic transmission of these neoplasms varies. Lipomas, for example, may have hereditary forms that follow an autosomal dominant pattern. Neurofibromas are commonly associated with neurofibromatosis type 1 (NF1), an autosomal dominant disorder. Transmission for other types like fibromas and hemangiomas may not be well-defined and could involve sporadic mutations or multifactorial inheritance.

Predisposition: Medium
Explanation of predisposition: We predict genetic risk by analyzing specific genetic variants within key genes associated with a condition. For each variant, we assess its impact on biological pathways that are known to influence the disease. The prediction takes into account both the clinical significance of each variant and the confidence in the prediction, which is determined by the quality and strength of the supporting scientific data and research.
Associated Genes
Gene Mutation Type Allele Confidence
FAM110C Frameshift A/T Medium
ANK2 Substitution T/C High
LRPPRC Duplication C/T High
ACTN2 Substitution A/C Medium
PHACTR2 Frameshift G/T Medium
Population Frequency By Gene

Population frequency indicates how common a specific genetic variant is within a group of people, expressed as a percentage. For example, if a gene variant has a frequency of 20%, it means about 20 out of 100 individuals carry that variant. This information helps researchers understand the potential impact of genetic variants on health and traits within different populations.

Gene Frequency
FAM110C 22%
ANK2 22%
LRPPRC 22%
ACTN2 18%
PHACTR2 9%
Associated Pathways

A pathway refers to a series of biochemical reactions and interactions that occur within cells, allowing for communication between genes, proteins, and metabolites. These pathways are crucial for various physiological functions, including neurotransmission, hormone signaling, and metabolic processes, and can influence behaviors and health outcomes when disrupted by genetic mutations.

Pathway Type Effects
REACT:R-HSA-74160 NF-kappa B Signaling Pathway Plays a role in synaptic plasticity
Possible Comobordities

Comorbidities are additional health conditions that often occur alongside a primary condition. For example, someone with ADHD may also have other related issues, such as anxiety or learning difficulties. These conditions are linked because they may share similar causes, such as genetics or brain chemistry, making it more likely for a person to experience both at the same time.

Gene Comorbidities Associated Mechanism
FAM110C Chronic Obstructive Pulmonary Disease (COPD) Mitochondrial impairment
ANK2 Osteoporosis Metabolic dysregulation
LRPPRC Osteoporosis Hormonal imbalance
ACTN2 Cancer Immune system dysfunction
PHACTR2 Diabetes Genetic predisposition

Recommendations for Medium Risk for Connective Tissue Benign Neoplasm

  • Consultation: Schedule a follow-up consultation with a primary care provider or genetic counselor.
  • Monitoring: Regularly monitor your health for early signs of the condition associated with your predisposition.
  • Lifestyle Adjustments: Implement moderate lifestyle changes to mitigate risk.
  • Personalized Lifestyle Plan:
    • Maintain a balanced diet rich in whole foods, lean protein, and healthy fats.
    • Engage in regular physical activity, such as walking, swimming, or light strength training.
    • Incorporate stress management techniques like deep breathing exercises or light yoga.
    • Limit alcohol consumption and reduce exposure to pollutants.

    For additional guidance on managing your predisposition: See treatment options for Digestive System Neoplasms.

Next Steps

Learn more about Connective Tissue Benign Neoplasm.

See predicted treatments for Digestive System Neoplasms.

Schedule a consultation with a GeneHealth representative to discuss results.

Appendix

Mutated Genes Found

Diseases Found

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