PrecisionHealth Treatment Report - Alzheimer's Disease
Member
Name: Jane Doe
Member ID: 1234
Sex at Birth: Female
Date of Birth: 12/12/1940
Provider
Name: Dr. Smith
Address: 100 Burdell Dr, Atlanta, GA
Sample Collection
Specimen ID: 3456
Specimen Type: Saliva
Amount: >2mL
Collection Tube: DNA Genotek Oragene•DNA (OG-600)
Collected: 6/24/2024
Sequencing
Test ID: 78910
Test Type: WES
Depth: 100x
Quality: Satisfactory
Sequenced: 9/30/2024
Executive Summary - Treatment Report for Alzheimer's Disease
Whole Exome Sequencing - Research Results
Key Results
- Treatment Efficacy: Based on genetic findings, treatments like Donepezil (Aricept) show high effectiveness in improving cognitive function, while others like Memantine (Namenda) and Rivastigmine (Exelon) offer medium efficacy for managing symptoms. Off-label treatments such as Vitamin E also show moderate potential for supporting brain health.
- Next Steps: It is recommended to discuss treatment options with your healthcare provider, considering the genetic insights provided. Depending on the effectiveness, adjustments to the treatment plan may be necessary. Follow-up with a cognitive specialist or neurologist may help refine therapy strategies and ensure the most effective combination of treatments.
Please note: This is a sample report with sample data.
*Disclaimers: This report is intended for research use only and is not diagnostic. Please consult with a healthcare provider for diagnoses and next steps.
**Provider recommendation: Please consult a genetic counselor or healthcare provider for next steps. If you do not have a healthcare provider, GeneHealth can assist with matching you to one.
***Treatment explanation: We provide recommendations for compassionate use drugs in cases where traditional treatment options have been exhausted. Treatments are to be discussed with your healthcare provider.
Treatments for Alzheimer's Disease
Explanation of Confidence: Our algorithms evaluate a series of FDA-approved treatments by analyzing the proteins associated with each drug and comparing them to the proteins linked to the patient's disease. The degree of alignment between these proteins determines the treatment’s predicted effectiveness, and precision is used to quantify the confidence in this prediction, ensuring that the recommended treatments are tailored to each individual’s unique genetic profile.
| Drug | Brand Name | Confidence | Description | Your Experience |
|---|---|---|---|---|
| Donepezil | Aricept | High |
Helps improve memory and thinking by increasing brain chemicals.
Improves cognitive function by inhibiting acetylcholinesterase, which increases levels of acetylcholine in the brain.
|
0%
0%
|
| Rivastigmine | Exelon | Medium |
Boosts memory and mental function by affecting brain chemicals.
Enhances cognitive function by inhibiting both acetylcholinesterase and butyrylcholinesterase, leading to increased acetylcholine levels.
|
0%
0%
|
| Galantamine | Razadyne | Medium |
Improves thinking and memory by increasing brain chemicals.
Boosts memory and cognitive function by inhibiting acetylcholinesterase and modulating nicotinic receptors.
|
0%
0%
|
| Memantine | Namenda | Medium |
Helps with memory by regulating brain signals.
Modulates glutamate activity by blocking NMDA receptors, reducing excitotoxicity and improving cognitive function.
|
0%
0%
|
| Aducanumab | Aduhelm | Medium |
Slows memory loss by reducing harmful brain deposits.
Reduces amyloid-beta plaques in the brain through targeted monoclonal antibody therapy, aiming to slow cognitive decline.
|
0%
0%
|
| Lecanemab | Leqembi | Medium |
May slow down disease progression by removing brain plaques.
Targets and helps clear amyloid-beta plaques in the brain using monoclonal antibody therapy to potentially slow disease progression.
|
0%
0%
|
Off-Label Treatments for Alzheimer's Disease
Off-label treatments involve using FDA-approved medications for conditions they weren’t originally approved to treat. These treatments are often considered when traditional, on-label options fail to provide effective results. Our prediction model also assesses the potential effectiveness of these off-label drugs by analyzing their protein associations with the patient's disease, offering additional personalized treatment options when conventional treatments are insufficient.
| Drug | Brand Name | Confidence | Description | Your Experience |
|---|---|---|---|---|
| Alpha-Tocopherol | Vitamin E | Medium |
An antioxidant that protects cells from damage and may support brain health.
Functions as a lipid-soluble antioxidant, protecting cell membranes from oxidative damage, and has potential neuroprotective properties.
|
0%
0%
|
| Levetiracetam | Keppra | Medium |
Used off-label to help control seizures and improve brain stability.
Acts as an anticonvulsant by binding to synaptic vesicle protein 2A, stabilizing neuronal activity and reducing seizure frequency.
|
0%
0%
|
| Midazolam Hydrochloride | Versed | Low |
Helps induce relaxation and calmness, often used in medical settings for anxiety.
A benzodiazepine that enhances the inhibitory effect of GABA at the GABA-A receptor, producing sedation and reducing anxiety.
|
0%
0%
|
| Midazolam | Dormicum | Low |
Induces calmness and sedation, often used in procedures or to manage severe anxiety.
Benzodiazepine that enhances GABAs effects, leading to sedation and relaxation in the central nervous system.
|
0%
0%
|