Cicatricial Entropion
Disease Details
Family Health Simplified
- Description
- Cicatricial entropion is a condition where scarring on the inner eyelid causes the eyelid to turn inward, leading to irritation and damage to the eyeball.
- Type
- Cicatricial entropion is not typically classified under a genetic transmission category, as it is usually a result of scarring (cicatricial) rather than inherited genetic factors. The condition is often caused by trauma, inflammation, infection, or surgical procedures that lead to scarring and contraction of the eyelid tissue, causing the eyelid margin to turn inward.
- Signs And Symptoms
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Cicatricial entropion is a condition where the eyelid turns inward due to scarring, leading to the eyelashes rubbing against the cornea.
**Signs and Symptoms:**
- Irritation and redness of the eye
- Sensation of a foreign body in the eye
- Watery eyes (epiphora)
- Pain or discomfort
- Corneal abrasions or ulcers
- Sensitivity to light (photophobia)
- Decreased vision if corneal damage occurs
If you experience these symptoms, you should seek medical evaluation for appropriate diagnosis and treatment. - Prognosis
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Cicatricial entropion is a condition where the eyelid margin turns inward due to scarring or contraction of the tissues. The prognosis often depends on the severity and underlying cause. Mild cases may respond well to conservative treatments such as lubricants or temporary sutures, while more severe cases usually require surgical intervention to correct the eyelid position.
Without treatment, cicatricial entropion can lead to chronic irritation, pain, and potential damage to the cornea, including ulceration and vision loss. Surgery generally has a good success rate, offering long-term relief and preservation of vision. Early diagnosis and management are key to preventing complications and ensuring a favorable outcome. - Onset
- Cicatricial entropion is characterized by the inward turning of the eyelid margin due to scarring and contraction of the conjunctiva and underlying tissues. This condition can develop slowly over time, and its onset is typically associated with chronic inflammation or trauma to the eyelid, which leads to cicatricial changes (scarring) and subsequent entropion. It is often seen in older adults as a consequence of conditions like trachoma, chronic blepharitis, or as a result of surgical procedures or injuries that cause scar formation.
- Prevalence
- The prevalence of cicatricial entropion, which is an inward turning of the eyelid due to scarring (cicatrix), is not well-documented in the general population. It is known to be more common in older adults and is often associated with conditions that cause chronic inflammation or scarring of the conjunctiva, such as trachoma, Stevens-Johnson syndrome, and ocular cicatricial pemphigoid. Specific prevalence may vary depending on the population studied and the underlying causes.
- Epidemiology
- Cicatricial entropion is a condition characterized by the inward turning of the eyelid, typically caused by scarring (cicatrix) of the inner eyelid. Epidemiologically, it is more commonly seen in older adults due to age-related changes in the skin and tissues around the eyelid. Other risk factors may include chronic inflammatory conditions such as trachoma, chemical injuries, and autoimmune diseases like ocular cicatricial pemphigoid. The exact prevalence varies based on underlying causes and geographic regions; for instance, trachoma-related cicatricial entropion is more common in areas with limited access to healthcare.
- Intractability
- Cicatricial entropion is not inherently intractable. It is a condition where the eyelid margin turns inward due to scarring (cicatrix) on the inner surface of the eyelid. There are various treatment options available, ranging from conservative approaches like lubricating eye drops and ointments to surgical interventions to correct the eyelid position. The choice of treatment depends on the severity and underlying cause of the entropion. With appropriate management, the condition can often be effectively treated.
- Disease Severity
- The term "cicatricial entropion" refers to a condition where the eyelid turns inward due to scarring. The severity of cicatricial entropion can vary based on the extent of the scarring and the degree to which the eyelid turns inward. Severe cases can cause significant discomfort, corneal irritation, and even vision impairment if left untreated.
- Healthcare Professionals
- Disease Ontology ID - DOID:13113
- Pathophysiology
- Cicatricial entropion occurs when the eyelid, usually the lower lid, turns inward due to scar formation. The pathophysiology involves fibrosis and contraction of the posterior lamella of the eyelid (including the tarsus and conjunctiva). This can result from chronic inflammatory conditions, trauma, or surgical complications, leading to the inward turning of the eyelid and causing the eyelashes to rub against the cornea and conjunctiva, causing irritation and potential damage.
- Carrier Status
- Cicatricial entropion is not a genetic condition, and therefore, carrier status is not applicable. It results from scarring and contraction of the conjunctiva or tarsal plate, which leads to inward turning of the eyelid margin.
- Mechanism
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Cicatricial entropion is a condition where the eyelid margin turns inward due to scarring or chronic inflammation. The inner surface of the eyelid comes into contact with the cornea and conjunctiva, causing discomfort, irritation, and potential damage to the eye.
### Mechanism:
1. **Scarring**: Chronic inflammation or trauma leads to the formation of scar tissue on the inner eyelid. Conditions like trachoma, Stevens-Johnson syndrome, chemical burns, or surgical procedures could result in cicatricial entropion.
2. **Contraction**: The scar tissue contracts over time, pulling the eyelid margin inward and affecting its normal position.
### Molecular Mechanisms:
1. **Fibrosis and Collagen Deposition**: Inflammatory responses result in the activation of fibroblasts, leading to excessive collagen deposition. This fibrotic process is mediated by growth factors like TGF-β (Transforming Growth Factor-beta).
2. **Matrix Metalloproteinases (MMPs)**: MMPs play a pivotal role in remodeling extracellular matrix components. An imbalance in these enzymes can contribute to abnormal tissue repair and scar formation.
3. **Inflammatory Cytokines**: Cytokines such as IL-1, IL-6, and TNF-α (Tumor Necrosis Factor-alpha) are involved in the inflammatory processes that precede fibrosis. Persistent inflammation can exacerbate scarring and contraction.
4. **Growth Factors**: Vascular Endothelial Growth Factor (VEGF) and Platelet-Derived Growth Factor (PDGF) are also implicated in the processes of angiogenesis and tissue fibrosis, contributing to eyelid scarring and entropion.
5. **Myofibroblasts**: The differentiation of fibroblasts into myofibroblasts, which express α-smooth muscle actin, is crucial for wound contraction. These cells exert contractile forces that draw the edges of the wound together, contributing to the inward turning of the eyelid.
Understanding these mechanisms can help in developing targeted therapies to mitigate or reverse the scarring and prevent the progression of cicatricial entropion. - Treatment
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Cicatricial entropion is a condition where the eyelid turns inward due to scarring, causing the eyelashes to rub against the cornea. Treatment options include:
1. **Lubricants**: Artificial tears and ointments can provide temporary relief.
2. **Botulinum Toxin (Botox)**: Injections can temporarily correct the eyelid position.
3. **Bandage Contact Lenses**: These can protect the cornea from damage.
4. **Surgery**: Various procedures can be performed to correct the eyelid position, such as:
- **Everting Sutures**: Temporary solution to evert the eyelid.
- **Skin Grafting**: Using a skin graft to reconstruct the eyelid.
- **Mucous Membrane Grafting**: Using mucous membrane tissue to replace scarred tissue.
It is essential to consult a specialist for an appropriate treatment plan tailored to the individual's condition. - Compassionate Use Treatment
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Cicatricial entropion is a condition where the eyelid turns inward due to scarring and contraction of the inner lining of the eyelid. Treatment primarily focuses on surgical correction to reposition the eyelid. There are no specific compassionate use treatments designated for cicatricial entropion.
Off-label or experimental treatments might include:
1. **Botulinum Toxin (Botox) Injections**: Though primarily used for cosmetic purposes and muscle spasticity, Botox can be injected to temporarily paralyze the muscles causing the inward turning of the eyelid.
2. **Fibrin Glue**: Used experimentally in some cases to support tissues during surgical procedures, although its primary use is for hemostasis and tissue adhesion.
3. **Amniotic Membrane Transplantation**: Occasionally used in ocular surface reconstruction; its application in cicatricial entropion is still experimental to help healing and reduce scarring.
4. **Mitomycin C**: An antimetabolite sometimes used off-label during surgical procedures to prevent scarring and recurrence of entropion.
Consulting with an ophthalmologist or an ocular plastic surgeon is essential for a tailored treatment plan. - Lifestyle Recommendations
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Cicatricial entropion is a condition where the eyelid margin turns inward due to scarring, irritation, or inflammation. Here are some lifestyle recommendations to manage this condition:
1. **Maintain Eyelid Hygiene**: Keep the eyelids clean to reduce the risk of infection and further irritation. Use mild cleansers recommended by your healthcare provider.
2. **Lubricating Eye Drops**: Regular use of lubricating or artificial tear drops can help relieve dryness and discomfort associated with entropion.
3. **Avoid Rubbing Eyes**: Rubbing can exacerbate the condition and cause further trauma to the eyelids and cornea.
4. **Sun Protection**: Wear sunglasses to protect your eyes from wind, dust, and direct sunlight, which can reduce irritation.
5. **Humidifiers**: Using a humidifier at home can help maintain moisture in the air and prevent the eyes from drying out.
6. **Medical Follow-Up**: Regular check-ups with an ophthalmologist are crucial to monitor the condition and receive timely interventions if the condition worsens.
7. **Temporary Measures**: In some cases, temporary taping of the eyelid or wearing specially designed glasses that hold the lid away from the eye can provide temporary relief.
If these measures don't help, surgical options may be considered to correct the position of the eyelid. - Medication
- Cicatricial entropion typically requires surgical intervention rather than medication to correct the inward turning of the eyelid caused by scar tissue contraction. Medications may be used to manage underlying causes or associated symptoms, such as using lubricating eye drops or ointments to protect the cornea, and antibiotics if there's an infection. However, definitive treatment usually involves surgical procedures to address the structural issues of the eyelid.
- Repurposable Drugs
- It appears there is no specific information available about repurposable drugs for cicatricial entropion. This condition typically involves treatments such as surgical correction, lubricating eye drops, or antibiotic ointments to manage symptoms and prevent infection. If considering medication for related symptoms or complications, please consult with a healthcare professional for personalized advice.
- Metabolites
- There are no specific metabolites directly associated with cicatricial entropion per se. Cicatricial entropion is a condition where the eyelid turns inward due to scarring and contraction of the inner lining of the eyelid. The focus for this condition is typically on the structural and anatomical changes rather than on specific metabolites. Proper diagnosis and treatment are essential, often requiring surgical intervention to correct the eyelid position.
- Nutraceuticals
- Cicatricial entropion refers to the inward turning of the eyelid caused by scarring and contraction of the conjunctiva and tarsal plate. It typically results from chronic inflammation, trauma, or certain diseases. There are no specific nutraceuticals known to treat cicatricial entropion directly. Management focuses on surgical interventions to correct the eyelid position and address the underlying cause. It is essential to consult with an ophthalmologist for proper diagnosis and treatment options.
- Peptides
- Cicatricial entropion is a condition where the eyelid margin undergoes inward turning due to scarring. Treatment approaches for this condition primarily target the underlying cause and mechanical correction of the eyelid position. While the use of peptides is not standard in current treatments for cicatricial entropion, future therapeutic approaches may explore the potential of peptides in promoting tissue repair and reducing fibrosis. The term "nan" could refer to the concept of nanotechnology, which also holds potential for innovative treatments in the form of targeted drug delivery systems, although it is not yet a conventional approach for this specific condition.