GeneHealth - Your precision medicine

Hypotrichosis Of Eyelid

Disease Details

Family Health Simplified

Buy Membership

Description: Hypotrichosis of the eyelid is a medical condition characterized by an abnormal lack of eyelashes.
Type: Hypotrichosis of the eyelid is typically transmitted as an autosomal dominant trait.
Signs And Symptoms: Hypotrichosis of the eyelid is characterized by the following signs and symptoms:

- Reduced number of eyelashes or complete absence of eyelashes
- Thinner eyelashes compared to normal
- Brittle or weak eyelashes that may break easily

Since nan (not applicable) indicates there's no information to be provided for that section, it's not relevant to include further details in this context.
Prognosis: Hypotrichosis of the eyelid, characterized by sparse or absent eyelashes, does not typically affect overall health. The prognosis is generally good, especially with treatment options available to promote eyelash growth. Latisse (bimatoprost ophthalmic solution) is commonly prescribed to enhance eyelash growth in affected individuals.
Onset: Hypotrichosis of the eyelid refers to a condition where there is less than the normal amount of hair on the eyelids, particularly affecting the eyelashes. The onset of hypotrichosis of the eyelid can vary depending on the underlying cause. It may be congenital, meaning present from birth, or acquired later in life due to various factors such as trauma, infections, inflammation, or underlying systemic conditions. Specific information about the onset age (nan) is not provided.
Prevalence: The prevalence of hypotrichosis of the eyelid is not well documented and specific data on its occurrence are scarce. This condition, characterized by inadequate or insufficient eyelashes, can vary greatly depending on the underlying causes, which might include genetic factors, medical conditions, or trauma.
Epidemiology: Epidemiology of hypotrichosis of the eyelid primarily involves individuals who experience inadequate or sparse eyelash growth. This condition can be either congenital or acquired. Congenitally, it can be associated with various genetic syndromes. Acquired cases may be linked to factors such as trauma, burns, infections, or the use of certain medications like chemotherapy agents. It is relatively rare in the general population.
Intractability: Hypotrichosis of the eyelid refers to a condition characterized by inadequate or sparse growth of eyelashes. While not generally considered intractable, its treatment options may depend on the underlying cause. Therapeutic approaches can include topical medications such as bimatoprost, which has been approved to promote eyelash growth. In cases where hypotrichosis is due to genetic or congenital factors, it may be more challenging to manage.
Disease Severity: Hypotrichosis of the eyelid refers to a condition characterized by insufficient or sparse growth of eyelashes. The severity of the condition can vary from mild, where there is a noticeable thinning of eyelashes, to more severe cases where there is almost a complete absence of eyelash growth. This condition may be congenital or acquired and can impact both eyelids.
Healthcare Professionals: Disease Ontology ID - DOID:11671
Pathophysiology: Hypotrichosis of the eyelid is a condition characterized by inadequate or sparse growth of eyelashes. The pathophysiology often involves disruptions in the normal hair follicle cycle, including the anagen (growth) phase. Factors that can contribute to this condition include genetic mutations, chronic blepharitis, trauma, chemotherapy, and certain systemic diseases. These disruptions can lead to abnormalities in the structure and function of the hair follicles, resulting in fewer or thinner eyelashes.
Carrier Status: Hypotrichosis of the eyelid is generally not associated with a specific genetic carrier status as it is not typically defined by a single genetic mutation passed in a simple Mendelian pattern (such as autosomal or X-linked recessive). It can be acquired or linked with complex genetic conditions. If the condition is part of a syndrome, genetic counseling may be necessary to determine the inheritance pattern and potential carrier status relevant to that specific syndrome.
Mechanism: Hypotrichosis of the eyelid is characterized by an abnormal deficiency of hair in the eyelashes.

**Mechanism:**
The condition arises when there is either a disruption in the growth cycle of eyelash hair follicles or a reduced number of hair follicles.

**Molecular Mechanisms:**
1. **Genetic Factors:** Mutations in specific genes can affect hair follicle development and cycling. For example, mutations in the FGF5 gene can disrupt normal hair elongation.
2. **Signaling Pathways:** Dysregulation in pathways such as Wnt/β-catenin, Hedgehog, and FGF (Fibroblast Growth Factor) signaling can impair follicle function and hair growth.
3. **Hormonal Influence:** Androgen receptors and fluctuations in hormone levels can influence hair growth positively or negatively.

These mechanisms collectively contribute to the inadequate production or retention of eyelash hair in individuals with hypotrichosis of the eyelid.
Treatment: The term "nan" seems to be unclear in this context. I'll provide information about the treatment for hypotrichosis of the eyelid.

Hypotrichosis of the eyelid, characterized by insufficient eyelash growth, can be treated with:

1. **Topical Medications**: Bimatoprost (brand name: Latisse) is an FDA-approved medication for improving eyelash growth, including length, thickness, and darkness.
2. **Nutritional Supplements**: Biotin and other vitamins may help in some cases, although their effectiveness is less certain.
3. **Eyelash Extensions or False Eyelashes**: These provide a cosmetic solution.
4. **Microneedling**: In some cases, this procedure may be suggested to stimulate hair growth.

Consultation with a healthcare provider is recommended for appropriate diagnosis and treatment.
Compassionate Use Treatment: For hypotrichosis of the eyelid, a compassionate use treatment might include the application of bimatoprost ophthalmic solution. Bimatoprost is an FDA-approved medication for hypotrichosis, but its use for individuals who don’t qualify for traditional treatments may classify it under compassionate use.

Off-label or experimental treatments may include latanoprost, another prostaglandin analogue, which is primarily approved for glaucoma but has been explored for promoting eyelash growth. Additionally, investigational therapies could involve gene therapy or advanced formulations of existing medications not yet approved for this specific condition. Always consult with a healthcare provider for the most appropriate treatment options.
Lifestyle Recommendations: Lifestyle recommendations for managing hypotrichosis of the eyelid, a condition characterized by reduced eyelash growth, include:

1. **Proper Eyelid Hygiene**: Regularly clean your eyelids to prevent infections that could exacerbate the condition.
2. **Avoid Eye Makeup**: Limit the use of eye makeup and ensure any used products are hypoallergenic to minimize irritation and allergic reactions.
3. **Gentle Handling**: Be gentle when removing makeup or rubbing your eyes to avoid pulling out eyelashes.
4. **Healthy Diet**: Maintain a balanced diet rich in vitamins and minerals, particularly biotin, vitamin E, and omega-3 fatty acids, which can support hair health.
5. **Regular Medical Checkups**: Consult with a healthcare provider for ongoing management and to address any underlying conditions that might affect eyelash growth.
6. **Consider Prescription Treatments**: Discuss the possibility of using medications, such as bimatoprost (Latisse), which is approved by the FDA for treating this condition.
7. **Avoid Use of False Eyelashes**: Minimize the use of false eyelashes and eyelash extensions, as the adhesives can damage natural lashes.

There are no specific activity or exercise limitations, but ensuring overall health and reducing stress can contribute to better hair and eyelash health.
Medication: For hypotrichosis of the eyelid, a common medication used is bimatoprost ophthalmic solution, often marketed under the brand name Latisse. It is applied to the base of the upper eyelashes to promote eyelash growth, making them longer, thicker, and darker.
Repurposable Drugs: Hypotrichosis of the eyelid is a condition characterized by an inadequate amount of eyelashes. One of the drugs repurposed for this condition is **bimatoprost**, originally used to treat glaucoma. It has been found to promote eyelash growth and is marketed under the brand name **Latisse** for this specific purpose.
Metabolites: Currently, there are no specific metabolites directly associated with hypotrichosis of the eyelid. This condition refers to the sparse or absent hair growth on the eyelids, particularly affecting the eyelashes. Often, treatment focuses on local applications and medications to promote hair growth, such as bimatoprost, rather than targeting specific metabolites.
Nutraceuticals: For hypotrichosis of the eyelid, nutraceuticals like biotin, omega-3 fatty acids, vitamins (such as A, C, E, and B-complex), and minerals like zinc can support overall hair health, including eyelashes. However, specific efficacy for treating hypotrichosis directly is limited in clinical evidence. Consulting a healthcare provider is recommended for personalized advice.
Peptides: Peptides are short chains of amino acids that can play a role in cell signaling and tissue repair. In the context of hypotrichosis of the eyelid, certain peptides are used in topical treatments to potentially stimulate hair growth. These peptides can promote hair follicle activity and enhance the health and growth rate of eyelashes when formulated in serums or other topical applications.