Amikacin
Drug Details
- Description
- Amikacin is an aminoglycoside antibiotic used to treat severe bacterial infections. It binds to bacterial 30S ribosomal subunits, inhibiting protein synthesis and leading to bacterial cell death. It's often used for infections caused by Gram-negative bacteria, especially those resistant to other antibiotics.
- Alternative Names
- Amikacin.
- Key Genes
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The key genes associated with amikacin resistance include:
1. **aac(6')-Ib**: Encodes aminoglycoside acetyltransferase.
2. **aph(3')-VI**: Encodes aminoglycoside phosphotransferase.
3. **armA**: Encodes 16S rRNA methyltransferase.
4. **rmtA to rmtG**: Encode various 16S rRNA methyltransferases.
5. **npmA**: Encodes ribosomal methyltransferase. - Drug Use
- Amikacin is an aminoglycoside antibiotic used to treat serious bacterial infections caused by Gram-negative bacteria, including those resistant to gentamicin and tobramycin. It is often used for infections of the respiratory tract, urinary tract, bones, joints, central nervous system, and skin.
- Genetic Factors Influencing Response
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