Aminoglycoside
Drug Details
- Description
- Aminoglycosides are a class of antibiotics that inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit. They are effective against many Gram-negative bacteria and some Gram-positive bacteria. Common examples include gentamicin, tobramycin, and amikacin. They are used to treat severe infections such as sepsis, respiratory infections, and certain types of bacterial meningitis. Due to potential nephrotoxicity and ototoxicity, their use is often monitored closely.
- Alternative Names
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Aminoglycosides include:
- Gentamicin
- Tobramycin
- Amikacin
- Neomycin
- Streptomycin - Key Genes
- Key genes for aminoglycoside resistance include aac (aminoglycoside acetyltransferase), ant (aminoglycoside nucleotidyltransferase), and aph (aminoglycoside phosphotransferase).
- Drug Use
- Aminoglycosides are used to treat serious bacterial infections, particularly those caused by Gram-negative organisms, such as Pseudomonas, Escherichia coli, and Klebsiella. They are commonly used in hospital settings for conditions like bacteremia, sepsis, respiratory tract infections, and urinary tract infections.
- Genetic Factors Influencing Response
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