Atorvastatin
Drug Details
- Description
- Atorvastatin is an HMG-CoA reductase inhibitor (statin) used to lower cholesterol and triglyceride levels in the blood. It helps reduce the risk of heart disease, heart attacks, and strokes by decreasing the production of cholesterol in the liver. It is often prescribed in conjunction with dietary and lifestyle changes.
- Alternative Names
- Atorvastatin.
- Key Genes
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Key genes involved in atorvastatin response include:
1. HMGCR (HMG-CoA reductase) – Target enzyme inhibited by atorvastatin.
2. SLCO1B1 (Solute Carrier Organic Anion Transporter Family Member 1B1) – Influences drug transport and plasma levels.
3. LDLR (Low-Density Lipoprotein Receptor) – Mediates clearance of LDL cholesterol.
4. APOE (Apolipoprotein E) – Affects lipid metabolism and response to statins. - Drug Use
- Atorvastatin is primarily used to lower cholesterol and triglyceride levels in the blood. It helps reduce the risk of cardiovascular disease and events such as heart attacks and strokes in individuals with elevated cholesterol levels. It is often prescribed alongside lifestyle changes such as diet and exercise.
- Genetic Factors Influencing Response
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