Doxorubicin
Drug Details
- Description
- Doxorubicin is an anthracycline antibiotic used as a chemotherapy agent. It works by intercalating DNA, disrupting topoisomerase-II-mediated DNA repair, and generating free radicals that damage cellular components. It's primarily used for treating various cancers, including lymphomas, leukemias, and solid tumors like breast and ovarian cancer.
- Alternative Names
- Doxorubicin is also known as Adriamycin.
- Key Genes
- Key genes associated with Doxorubicin response include ABCC1, ABCB1, NQO1, TOP2A, and SLCO1B3.
- Drug Use
- Doxorubicin is used in chemotherapy to treat various cancers, including breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphoblastic leukemia.
- Genetic Factors Influencing Response
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