Fentanyl
Drug Details
- Description
- Fentanyl is a powerful synthetic opioid analgesic, similar to morphine but 50-100 times more potent. It is used medically to treat severe pain, such as pain from surgery or chronic pain in patients who are physically tolerant to other opioids. It is highly addictive and has a high potential for overdose and death.
- Alternative Names
- Fentanyl.
- Key Genes
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Key genes involved in fentanyl metabolism and response include:
1. CYP3A4: Primary enzyme in fentanyl metabolism.
2. CYP3A5: Also contributes to metabolism.
3. POR: Influences CYP enzyme activity.
4. ABCB1 (MDR1): Affects drug transport and bioavailability.
5. OPRM1: Encodes the mu-opioid receptor, impacting drug response.
6. COMT: Influences pain perception and opioid response. - Drug Use
- Fentanyl is a synthetic opioid used medically for severe pain management, typically in cancer patients or after surgery. It is highly potent, much stronger than morphine or heroin. Non-medical use can lead to significant overdose risk, respiratory depression, and death.
- Genetic Factors Influencing Response
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