Glucocorticoid
Drug Details
- Description
- Glucocorticoids are a class of corticosteroids that bind to the glucocorticoid receptor. They are anti-inflammatory and immunosuppressive agents used to treat conditions like asthma, allergies, rheumatoid arthritis, and autoimmune diseases. Common glucocorticoids include prednisone, dexamethasone, and hydrocortisone. They reduce inflammation by blocking the migration of white blood cells and suppressing the immune system.
- Alternative Names
- Glucocorticoid is also known as corticosteroid.
- Key Genes
- Key genes involved in glucocorticoid function include NR3C1 (Glucocorticoid Receptor), HSD11B1 (11β-Hydroxysteroid Dehydrogenase Type 1), FKBP5 (FK506 Binding Protein 5), and SGK1 (Serine/Threonine-Protein Kinase SGK1).
- Drug Use
- Glucocorticoids are used to reduce inflammation and suppress the immune system. They treat conditions like asthma, COPD, rheumatoid arthritis, lupus, and allergic reactions. They are also used in managing adrenal insufficiency.
- Genetic Factors Influencing Response
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