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Hormonal

Drug Details

Description
Hormonal drugs are medications that influence the body's endocrine system, affecting hormone levels and their actions. They can be used for a variety of conditions, including hormone replacement therapy, contraceptives, cancer treatment, and management of menopausal symptoms. Examples include estrogens, progestins, androgens, thyroid hormones, and insulin.
Alternative Names
GnRH: Gonadotropin-Releasing Hormone
HRT: Hormone Replacement Therapy
LH: Luteinizing Hormone
FSH: Follicle-Stimulating Hormone
T3: Triiodothyronine
T4: Thyroxine
ADH: Antidiuretic Hormone
ACTH: Adrenocorticotropic Hormone
Key Genes
Key genes involved in hormonal regulation include:

1. HSD3B1 and HSD3B2 - enzymes in steroid hormone biosynthesis.
2. CYP19A1 (Aromatase) - converts androgens to estrogens.
3. NR3C1 (Glucocorticoid receptor) - mediates cortisol effects.
4. ESR1 and ESR2 - estrogen receptors.
5. AR - androgen receptor.
6. PGR - progesterone receptor.
7. THRB - thyroid hormone receptor beta.
8. INS - insulin gene, relevant in metabolic hormone regulation.
9. GHR - growth hormone receptor.

These genes are crucial in the synthesis, regulation, and response to various hormones in the body.
Drug Use
Hormonal drugs are used for various conditions, including contraception, hormone replacement therapy, and treating hormonal imbalances. Examples include birth control pills, estrogen, and testosterone therapy. They work by altering or supplementing hormone levels in the body.
Genetic Factors Influencing Response

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