Hydrochlorothiazide
Drug Details
- Description
- Hydrochlorothiazide is a thiazide diuretic used to treat hypertension (high blood pressure) and edema (fluid retention) associated with conditions such as heart failure, liver cirrhosis, and kidney disorders. It helps the kidneys remove excess salt and water from the body, reducing blood volume and pressure.
- Alternative Names
- HCTZ
- Key Genes
- Key genes: SLC12A3 (encodes NCC, the target of hydrochlorothiazide), KCNJ1 (influences drug response), CACNB2, CACNA1C (associated with blood pressure response), and various genes involved in electrolyte transport and metabolism.
- Drug Use
- Hydrochlorothiazide is a diuretic used to treat high blood pressure and fluid retention (edema) due to heart failure, kidney disorders, liver disease, or certain medications.
- Genetic Factors Influencing Response
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