Irinotecan
Drug Details
- Description
- Irinotecan is a chemotherapy drug used to treat colorectal cancer. It is a topoisomerase inhibitor that prevents DNA replication, leading to cell death. It is often administered intravenously and can cause side effects such as diarrhea, nausea, and neutropenia.
- Alternative Names
- Irinotecan, also known as CPT-11.
- Key Genes
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The key genes for Irinotecan metabolism and response are:
1. UGT1A1
2. CES1
3. CES2
4. ABCB1
5. ABCC2 - Drug Use
- Irinotecan is used primarily for the treatment of metastatic colorectal cancer, often in combination with other drugs. It can also be used to treat other cancers such as lung cancer and pancreatic cancer.
- Genetic Factors Influencing Response
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