Kanamycin
Drug Details
- Description
- Kanamycin is an aminoglycoside antibiotic used to treat various bacterial infections, including tuberculosis and infections caused by Gram-negative bacteria. It inhibits protein synthesis by binding to the 30S ribosomal subunit. It's typically administered via injection.
- Alternative Names
- Kanamycin.
- Key Genes
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Key genes related to kanamycin resistance include:
1. **aph(3')-Ia** - Encodes aminoglycoside phosphotransferase.
2. **aadA** - Encodes aminoglycoside adenylyltransferase.
3. **rpsL** - Mutations in ribosomal protein S12 confer resistance.
4. **methyltransferases** - Genes like armA that methylate 16S rRNA reduce kanamycin binding.
These genes can confer resistance through enzyme modification or target alteration. - Drug Use
- Kanamycin is an antibiotic used primarily to treat severe bacterial infections, including multi-drug resistant tuberculosis and certain gram-negative bacterial infections. It is administered via injection.
- Genetic Factors Influencing Response
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