Methotrexate
Drug Details
- Description
- Methotrexate is a folate antimetabolite used to treat certain types of cancer, severe psoriasis, and rheumatoid arthritis by inhibiting DNA synthesis, repair, and cellular replication.
- Alternative Names
- MTX.
- Key Genes
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The key genes associated with methotrexate response and toxicity include:
1. **MTHFR (Methylenetetrahydrofolate reductase):** Variants can affect drug metabolism and toxicity.
2. **TYMS (Thymidylate synthase):** Polymorphisms may influence drug efficacy and side effects.
3. **ABCC2 (ATP-binding cassette sub-family C member 2):** Involved in drug transport and clearance.
4. **SLC19A1 (Solute carrier family 19 member 1):** Functions in drug uptake into cells.
5. **ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase):** Plays a role in drug mechanism. - Drug Use
- Methotrexate is used to treat certain types of cancer, severe psoriasis, and rheumatoid arthritis. It can slow the growth of cancer cells and suppress the immune system.
- Genetic Factors Influencing Response
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