Mtor
Drug Details
- Description
- mTOR inhibitors are drugs that block the activity of the mammalian target of rapamycin (mTOR), a protein kinase involved in cell growth, proliferation, and survival. They are used in cancer therapy, immunosuppression, and various other medical conditions. Key examples include everolimus and sirolimus.
- Alternative Names
- mTOR: Mammalian Target of Rapamycin.
- Key Genes
- Key genes involved in mTOR signaling include MTOR, RPTOR, MLST8, AKT1, TSC1, TSC2, DEPTOR, PRR5, and RHEB.
- Drug Use
- The mTOR (mammalian target of rapamycin) pathway is targeted by drugs like rapamycin (sirolimus) and its analogs (e.g., everolimus, temsirolimus) for their immunosuppressive and antitumor effects. These drugs are used in organ transplantation to prevent rejection and in cancer therapy to inhibit cell growth and proliferation.
- Genetic Factors Influencing Response
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