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Opioid

Drug Details

Description
Opioids are a class of drugs that include both prescription pain relievers (like oxycodone and morphine) and illegal drugs (like heroin). They work by binding to opioid receptors in the brain and body to reduce the perception of pain but can also produce euphoria. Use can lead to dependence, addiction, and serious side effects, including respiratory depression and death.
Alternative Names
Opioid.
Key Genes
Key genes related to opioid pharmacodynamics and pharmacokinetics include OPRM1, which encodes the mu-opioid receptor, CYP2D6 and CYP3A4, involved in opioid metabolism, and ABCB1, which encodes P-glycoprotein affecting drug transport. Other relevant genes include COMT, UGT2B7, and OPRK1.
Drug Use
Opioids are used to treat moderate to severe pain, often post-surgery or injury. They also manage chronic pain conditions. Common opioids include morphine, oxycodone, and fentanyl.
Genetic Factors Influencing Response

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