Platinum
Drug Details
- Description
- Platinum-based drugs, such as cisplatin, carboplatin, and oxaliplatin, are chemotherapy agents used to treat various cancers. They work by forming platinum-DNA adducts, causing DNA cross-linking that inhibits replication and transcription, leading to cell death.
- Alternative Names
- Pt
- Key Genes
- The key genes associated with platinum drug response are ERCC1, ERCC2, GSTP1, XRCC1, and BRCA1.
- Drug Use
- Platinum is often used in chemotherapy drugs, such as cisplatin, carboplatin, and oxaliplatin, to treat various types of cancer by damaging DNA in cancer cells, inhibiting their ability to replicate and leading to cell death.
- Genetic Factors Influencing Response
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