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Pravastatin

Drug Details

Description
Pravastatin is a statin used to lower cholesterol and triglycerides in the blood. It works by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol synthesis, thereby reducing the risk of cardiovascular disease.
Alternative Names
Pravastatin is also known by the brand name Pravachol.
Key Genes
Key genes for pravastatin include SLCO1B1, which encodes the OATP1B1 transporter involved in hepatic uptake, and HMGCR, which encodes the enzyme HMG-CoA reductase, the drug's target. Variants in SLCO1B1 can affect drug metabolism and efficacy.
Drug Use
Pravastatin is used to lower cholesterol and triglycerides in the blood, and to reduce the risk of heart attack, stroke, and related health conditions.
Genetic Factors Influencing Response

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