Rosuvastatin
Drug Details
- Description
- Rosuvastatin is an HMG-CoA reductase inhibitor, also known as a statin, used to lower cholesterol and triglycerides in the blood. It helps reduce the risk of cardiovascular events such as heart attack and stroke.
- Alternative Names
- Rosuvastatin calcium
- Key Genes
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- **SLCO1B1:** Gene encoding OATP1B1, important for hepatic uptake.
- **ABCB1:** Gene encoding P-glycoprotein, affects drug efflux.
- **CYP2C9:** Enzyme involved in metabolism.
- **CETP:** Gene associated with lipid levels response.
- **HMGCR:** Target gene encoding HMG-CoA reductase. - Drug Use
- Rosuvastatin is used to lower cholesterol and triglyceride levels in the blood, reducing the risk of cardiovascular disease, heart attacks, and strokes. It belongs to the statin class of drugs.
- Genetic Factors Influencing Response
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