Simvastatin
Drug Details
- Description
- Simvastatin is a lipid-lowering medication that belongs to the statin class. It works by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol synthesis, thus lowering LDL cholesterol and triglycerides while increasing HDL cholesterol.
- Alternative Names
- Simvastatin
- Key Genes
- Key genes associated with simvastatin metabolism and response include SLCO1B1, CYP3A4, CYP3A5, and ABCB1. Variants in these genes can influence drug efficacy and risk of adverse effects.
- Drug Use
- Simvastatin is used to lower cholesterol and triglycerides in the blood. It helps reduce the risk of heart attack, stroke, and other heart complications in people with certain risk factors. It is commonly prescribed for individuals with hyperlipidemia or cardiovascular disease.
- Genetic Factors Influencing Response
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