Statins
Drug Details
- Description
- Statins are a class of drugs used to lower cholesterol levels in the blood, particularly low-density lipoprotein (LDL) cholesterol. They work by inhibiting the enzyme HMG-CoA reductase, which is involved in the production of cholesterol in the liver. Common statins include atorvastatin, simvastatin, and rosuvastatin. They are used to reduce the risk of cardiovascular events such as heart attack and stroke.
- Alternative Names
- Common statins include Atorvastatin, Simvastatin, Rosuvastatin, Pravastatin, Lovastatin, and Fluvastatin.
- Key Genes
- Key genes involved in statin metabolism and response include HMGCR, SLCO1B1, ABCB1, and CYP3A4. Variants in SLCO1B1, in particular, can affect statin-induced myopathy risk.
- Drug Use
- Statins are used to lower LDL cholesterol levels, reduce the risk of cardiovascular disease, and prevent heart attacks and strokes. They work by inhibiting the enzyme HMG-CoA reductase in the liver.
- Genetic Factors Influencing Response
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