Tacrolimus
Drug Details
- Description
- Tacrolimus is an immunosuppressant used primarily to prevent organ transplant rejection. It functions by inhibiting calcineurin, thus reducing the activity of T-cells and lowering the immune response.
- Alternative Names
- Tacrolimus (brand names: Prograf, Advagraf, Envarsus)
- Key Genes
- Key genes for Tacrolimus include CYP3A5, CYP3A4, and ABCB1. Variants in these genes can affect the drug's metabolism and transport, impacting dosing and efficacy.
- Drug Use
- Tacrolimus is an immunosuppressive drug used primarily to prevent organ transplant rejection and to treat severe atopic dermatitis and certain autoimmune diseases.
- Genetic Factors Influencing Response
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