Thiopurine
Drug Details
- Description
- Thiopurines are a class of immunosuppressive drugs that include azathioprine, mercaptopurine, and thioguanine. They are used primarily to treat autoimmune diseases and certain types of cancer by interfering with DNA synthesis and inhibiting the proliferation of immune cells.
- Alternative Names
- Thiopurine.
- Key Genes
- Key genes associated with Thiopurine metabolism are TPMT (Thiopurine S-methyltransferase) and NUDT15 (Nudix Hydrolase 15).
- Drug Use
- Thiopurine drugs, such as azathioprine and mercaptopurine, are used to treat autoimmune conditions like Crohn's disease, ulcerative colitis, and rheumatoid arthritis, as well as prevent organ transplant rejection.
- Genetic Factors Influencing Response
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