Tobramycin
Drug Details
- Description
- Tobramycin is an aminoglycoside antibiotic used to treat bacterial infections, particularly Gram-negative infections. It works by inhibiting protein synthesis in bacteria, leading to cell death. It is available in various forms, including eye drops, inhalation solution, and injectable formulations.
- Alternative Names
- Tobramycin.
- Key Genes
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Key genes associated with tobramycin include:
- rrs: Encodes the 16S rRNA which can mutate and confer resistance.
- aac(6')-I: Encodes an aminoglycoside 6'-N-acetyltransferase that can inactivate tobramycin.
- aph(2''): Encodes an aminoglycoside phosphotransferase enzyme that can modify and inactivate tobramycin. - Drug Use
- Tobramycin is an aminoglycoside antibiotic used to treat bacterial infections, particularly gram-negative bacteria, including respiratory, urinary tract, skin, and soft tissue infections, as well as conjunctivitis when administered as an eye drop.
- Genetic Factors Influencing Response
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