Tramadol
Drug Details
- Description
- Tramadol is a synthetic opioid analgesic used to treat moderate to severe pain. It works by binding to opioid receptors and inhibiting the reuptake of norepinephrine and serotonin, which helps modulate pain signals. Tramadol is available in immediate-release and extended-release formulations. It has the potential for dependence and abuse, so it is classified as a controlled substance in many countries.
- Alternative Names
- Tramadol is often known by the brand name Ultram.
- Key Genes
- Key genes involved in tramadol's metabolism and response are CYP2D6, CYP3A4, and SLC22A2. CYP2D6 is particularly important for converting tramadol into its more potent active metabolite, O-desmethyltramadol.
- Drug Use
- Tramadol is used to treat moderate to severe pain.
- Genetic Factors Influencing Response
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