Your PrecisionHealth Report (Sample)
Your PrecisionHealth Report provides personalized insights into your genetic makeup, health risks, and actionable recommendations to optimize your well-being. Explore your results and select diseases to track below. Please note: GeneHealth provides advanced genomic insights as a research tool and is not intended for diagnostic use or as a substitute for professional medical advice.
This is a sample report with sample data.
Summary
Your genetic profile indicates predispositions to several key health conditions. These include genetic disorders, metabolic disorders, and cardiovascular diseases. There are also notable risks for neurological conditions, autoimmune disorders, and various types of cancers. Additionally, there is a predisposition to gastrointestinal, endocrine, genitourinary, and skin disorders. Regular health monitoring and proactive management are recommended to address these potential risks and maintain overall well-being.
Explore
How to Read Your GeneHealth Sample Report
Your GeneHealth sample report provides insights into various aspects of your genetic profile, focusing on broad disease categories, specific diseases, pathways, and genes relevant to your health.
Key Elements
- Broad Disease Categories: These categories encompass major health conditions that may have genetic implications.
- Specific Diseases: Detailed information on specific diseases associated with your genetic profile.
- Pathways: Genetic pathways involved in various biological processes, identified by Reactome pathway identifiers (e.g., REACT:R-HSA-2168880). These pathways help understand how genetic variations may influence biological functions.
- Genes: Genes analyzed in your report that play a role in disease susceptibility or other health-related factors (e.g., ELN, PCSK9).
How to Interpret
- Understanding Disease Categories: Each category highlights genetic predispositions or risks associated with related diseases.
- Specific Disease Insights: Detailed explanations provide context on how genetic variations may impact specific diseases.
- Pathway Analysis: Insights into genetic pathways offer a deeper understanding of biological mechanisms affected by your genetic profile.
- Gene Variants: Information on specific genes helps you comprehend their role in health outcomes and potential implications for personalized health management.
Next Steps
Review each section to gain a comprehensive understanding of your genetic insights. Explore personalized treatment options through our treatment portal.
Brain Health (Neurological Disorders) ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Alzheimer's Disease | PHACTR2, TMEM45A, FOXD4, MROH2B, ANK2 | REACT:R-HSA-6805567 |
High
|
Nervous System Diseases | GRM6, ACAD9-DT, SLC12A7, MRPL36, PHACTR2 | REACT:R-HSA-6805567, REACT:R-HSA-74160, REACT:R-HSA-1430728, REACT:R-HSA-76002, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Neurodegenerative Diseases | ACAD9-DT, TMEM45A, SLC12A7, MRPL36, GTPBP8 | REACT:R-HSA-6805567, REACT:R-HSA-74160, REACT:R-HSA-1430728, REACT:R-HSA-76002, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Cerebrovascular Disorders | MRPL36, PUM3, MROH2B, ANK2, NQO2 | REACT:R-HSA-6805567 |
Medium
|
Central Nervous System Diseases | SDHA, ACAD9-DT, PUM3, ZDHHC11, ACAD9 | REACT:R-HSA-74160, REACT:R-HSA-1430728, REACT:R-HSA-76002, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Brain Diseases, Metabolic | SDHA, FOXD4, SLC12A7, LRPPRC, ACTN2 | REACT:R-HSA-1430728, REACT:R-HSA-611105 |
Medium
|
Neuromuscular Diseases | ACAD9, PUM3, ACAD9-DT, ZNF518B, ANK2 | REACT:R-HSA-1430728, REACT:R-HSA-76002, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Lysosomal Storage Diseases, Nervous System | ZFYVE9, GTPBP8, PUM3, ANK2, SLC12A7 | REACT:R-HSA-1430728, REACT:R-HSA-611105 |
Medium
|
Neurologic Manifestations | GSTM4, GRM6, FAM110C, ACAD9-DT, MRPL36 | REACT:R-HSA-1430728, REACT:R-HSA-611105 |
Medium
|
Cranial Nerve Diseases | GRM6, PUM3, LRPPRC, MROH2B, ANK2 | REACT:R-HSA-611105 |
Medium
|
Spinal Cord Ischemia | ACAD9-DT, LRPPRC, PHACTR2, SDHA, GRM6 | REACT:R-HSA-76005 |
Medium
|
Autoimmune Disorders ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Connective Tissue Diseases | ZDHHC11, ZNF518B, GSTM4, PUM3, GTPBP8 | REACT:R-HSA-6805567, REACT:R-HSA-76002 |
Low
|
Immune System Diseases | SLC12A7, ANK2, ZFYVE9, FOXD4, ACAD9-DT | REACT:R-HSA-6805567, REACT:R-HSA-74160, REACT:R-HSA-76002 |
Medium
|
Autoimmune Diseases | PUM3, ANK2, MRPL36, GSTM4, TMEM45A | REACT:R-HSA-6805567, REACT:R-HSA-76002 |
Medium
|
Demyelinating Autoimmune Diseases, Cns | PHACTR2, TMEM45A, FOXD4, MROH2B, ANK2 | REACT:R-HSA-6805567 |
Low
|
Heart Health (Cardiovascular Diseases) ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Cardiovascular Abnormalities | MROH2B, GTPBP8, SLC12A7, PHACTR2, LRPPRC | REACT:R-HSA-6805567 |
Medium
|
Cardiomyopathy, Hypertrophic | FOXD4, GSTM4, SDHA, TMEM45A, ZDHHC11 | REACT:R-HSA-6805567 |
Medium
|
Vascular Diseases | LRPPRC, ZNF518B, TMEM45A, GSTM4, PHACTR2 | REACT:R-HSA-76002, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Hypertension | ACAD9-DT, TMEM45A, GRM6, NQO2, ZNF518B | REACT:R-HSA-76002, REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Coronary Artery Disease | GTPBP8, SLC12A7, MRPL36, ZDHHC11, GSTM4 | REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Dermatological Diseases ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Skin And Connective Tissue Diseases | GTPBP8, LRPPRC, ZFYVE9, SDHA, ZDHHC11 | REACT:R-HSA-6805567, REACT:R-HSA-74160, REACT:R-HSA-1430728, REACT:R-HSA-76002, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Endocrine Disorders ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Endocrine System Diseases | SLC12A7, ZNF518B, PUM3, MRPL36, FOXD4 | REACT:R-HSA-74160 |
Medium
|
Gastrointestinal Disorders ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Digestive System Diseases | GTPBP8, ACAD9-DT, GRM6, MRPL36, FOXD4 | REACT:R-HSA-74160, REACT:R-HSA-76002 |
Medium
|
Gastrointestinal Diseases | LRPPRC, FOXD4, GTPBP8, SDHA, MRPL36 | REACT:R-HSA-74160, REACT:R-HSA-76002 |
Medium
|
Intestinal Diseases | FOXD4, GTPBP8, ZDHHC11, ZNF518B, MRPL36 | REACT:R-HSA-74160, REACT:R-HSA-76002 |
Medium
|
Genitourinary Disorders ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Male Urogenital Diseases | ANK2, FOXD4, ZNF518B, GSTM4, MRPL36 | REACT:R-HSA-74160, REACT:R-HSA-1430728 |
Medium
|
Hematological Disorders ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Hemic And Lymphatic Diseases | ZDHHC11, ACAD9-DT, SDHA, MRPL36, TMEM45A | REACT:R-HSA-74160, REACT:R-HSA-76002, REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Hematologic Diseases | ACTN2, TMEM45A, FAM110C, ACAD9, NQO2 | REACT:R-HSA-76002, REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Blood Coagulation Disorders | ZNF518B, FOXD4, GTPBP8, MRPL36, ACTN2 | REACT:R-HSA-76002, REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Hemorrhagic Disorders | GTPBP8, PHACTR2, ACAD9-DT, SDHA, ZNF518B | REACT:R-HSA-76002, REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Thrombophilia | SLC12A7, GRM6, ZFYVE9, ZNF518B, GSTM4 | REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Metabolic Disorders ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Carbohydrate Metabolism, Inborn Errors | MROH2B, ACAD9, SLC12A7, GSTM4, ACTN2 | REACT:R-HSA-1430728, REACT:R-HSA-611105 |
Medium
|
Lipid Metabolism Disorders | ZNF518B, FOXD4, GSTM4, SDHA, TMEM45A | REACT:R-HSA-1430728 |
Medium
|
Lipidoses | FAM110C, SDHA, MROH2B, SLC12A7, ZNF518B | REACT:R-HSA-1430728 |
Medium
|
Obesity | ZNF518B, ZFYVE9, GRM6, GTPBP8, FOXD4 | REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Diabetes Mellitus, Type 1 | GRM6, PHACTR2, ACTN2, PUM3, ZDHHC11 | REACT:R-HSA-114608 |
Medium
|
Lipid Metabolism, Inborn Errors | MROH2B, ACTN2, ACAD9, ZDHHC11, ACAD9-DT | REACT:R-HSA-1430728, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005 |
Medium
|
Musculoskeletal Diseases ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Musculoskeletal Diseases | MRPL36, ANK2, ACTN2, SDHA, GTPBP8 | REACT:R-HSA-74160, REACT:R-HSA-1430728, REACT:R-HSA-76002, REACT:R-HSA-611105 |
Medium
|
Muscular Diseases | SDHA, ZFYVE9, SLC12A7, PHACTR2, TMEM45A | REACT:R-HSA-611105 |
Medium
|
Cancers (Neoplastic Diseases) ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Genital Neoplasms, Male | ZFYVE9, ACAD9, ZDHHC11, MRPL36, NQO2 | REACT:R-HSA-6805567 |
Medium
|
Prostatic Neoplasms | ZDHHC11, TMEM45A, LRPPRC, ZFYVE9, SLC12A7 | REACT:R-HSA-6805567 |
Medium
|
Breast Neoplasms | FAM110C, SDHA, LRPPRC, ACAD9-DT, GRM6 | REACT:R-HSA-74160 |
Medium
|
Gastrointestinal Neoplasms | SDHA, MRPL36, GSTM4, MROH2B, ACAD9 | REACT:R-HSA-74160 |
Medium
|
Digestive System Neoplasms | FAM110C, ANK2, LRPPRC, ACTN2, PHACTR2 | REACT:R-HSA-74160 |
Medium
|
Obstetric and Gynecological Disorders ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Female Urogenital Diseases And Pregnancy Complications | TMEM45A, ACAD9, SDHA, GRM6, PHACTR2 | REACT:R-HSA-74160 |
Medium
|
Ophthalmological Diseases ▼
Disease | Associated Genes | Pathways | Predisposition |
---|---|---|---|
Eye Diseases, Hereditary | SDHA, ACAD9-DT, NQO2, ZFYVE9, ANK2 | REACT:R-HSA-611105 |
Medium
|
Mendelian Disorders ▼
Based on our analysis of your DNA exome, we did not predict any Ophthalmological diseases.
Cerebrovascular disease primarily includes conditions such as stroke, aneurysms, and arteriosclerosis affecting the blood vessels in the brain.
Your Relationship with Cerebrovascular Disorders
Lysosomal storage diseases (LSDs) are a group of inherited metabolic disorders characterized by an abnormal build-up of various toxic materials in the body's cells due to enzyme deficiencies.
Your Relationship with lysosomal storage diseases, nervous system
Cardiovascular phenotypes can refer to a range of physical characteristics or conditions related to the heart and blood vessels.
Your Relationship with Cardiovascular Abnormalities
Coronary artery disease (CAD) is a multifactorial disease, meaning it results from a combination of genetic and environmental factors.
Your Relationship with Coronary Artery Disease
Haemorrhagic disorders can be broadly classified into several types, including hemophilia, von Willebrand disease, and platelet function disorders.
Your Relationship with Hemorrhagic Disorders
Musculoskeletal disorders are primarily non-genetic in nature, as they often result from lifestyle factors, repetitive motion, injuries, or age-related wear and tear.
Your Relationship with musculoskeletal diseases
Trophoblastic neoplasm is a type of gestational trophoblastic disease (GTD) that arises from abnormal growth of trophoblastic cells, which are cells that normally develop into the placenta during pregnancy.
Your Relationship with Prostatic Neoplasms