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Your PrecisionHealth Report (Sample)

Your PrecisionHealth Report provides personalized insights into your genetic makeup, health risks, and actionable recommendations to optimize your well-being. Explore your results and select diseases to track below. Please note: GeneHealth provides advanced genomic insights as a research tool and is not intended for diagnostic use or as a substitute for professional medical advice.

This is a sample report with sample data.

Summary

Your genetic profile indicates predispositions to several key health conditions. These include genetic disorders, metabolic disorders, and cardiovascular diseases. There are also notable risks for neurological conditions, autoimmune disorders, and various types of cancers. Additionally, there is a predisposition to gastrointestinal, endocrine, genitourinary, and skin disorders. Regular health monitoring and proactive management are recommended to address these potential risks and maintain overall well-being.

Explore

How to Read Your GeneHealth Sample Report

Your GeneHealth sample report provides insights into various aspects of your genetic profile, focusing on broad disease categories, specific diseases, pathways, and genes relevant to your health.

Key Elements

  • Broad Disease Categories: These categories encompass major health conditions that may have genetic implications.
  • Specific Diseases: Detailed information on specific diseases associated with your genetic profile.
  • Pathways: Genetic pathways involved in various biological processes, identified by Reactome pathway identifiers (e.g., REACT:R-HSA-2168880). These pathways help understand how genetic variations may influence biological functions.
  • Genes: Genes analyzed in your report that play a role in disease susceptibility or other health-related factors (e.g., ELN, PCSK9).

How to Interpret

  • Understanding Disease Categories: Each category highlights genetic predispositions or risks associated with related diseases.
  • Specific Disease Insights: Detailed explanations provide context on how genetic variations may impact specific diseases.
  • Pathway Analysis: Insights into genetic pathways offer a deeper understanding of biological mechanisms affected by your genetic profile.
  • Gene Variants: Information on specific genes helps you comprehend their role in health outcomes and potential implications for personalized health management.

Next Steps

Review each section to gain a comprehensive understanding of your genetic insights. Explore personalized treatment options through our treatment portal.

Brain Health (Neurological Disorders)
Disease Associated Genes Pathways Predisposition
Alzheimer's Disease PHACTR2, TMEM45A, FOXD4, MROH2B, ANK2 REACT:R-HSA-6805567
High
Nervous System Diseases GRM6, ACAD9-DT, SLC12A7, MRPL36, PHACTR2 REACT:R-HSA-6805567, REACT:R-HSA-74160, REACT:R-HSA-1430728, REACT:R-HSA-76002, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Neurodegenerative Diseases ACAD9-DT, TMEM45A, SLC12A7, MRPL36, GTPBP8 REACT:R-HSA-6805567, REACT:R-HSA-74160, REACT:R-HSA-1430728, REACT:R-HSA-76002, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Cerebrovascular Disorders MRPL36, PUM3, MROH2B, ANK2, NQO2 REACT:R-HSA-6805567
Medium
Central Nervous System Diseases SDHA, ACAD9-DT, PUM3, ZDHHC11, ACAD9 REACT:R-HSA-74160, REACT:R-HSA-1430728, REACT:R-HSA-76002, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Brain Diseases, Metabolic SDHA, FOXD4, SLC12A7, LRPPRC, ACTN2 REACT:R-HSA-1430728, REACT:R-HSA-611105
Medium
Neuromuscular Diseases ACAD9, PUM3, ACAD9-DT, ZNF518B, ANK2 REACT:R-HSA-1430728, REACT:R-HSA-76002, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Lysosomal Storage Diseases, Nervous System ZFYVE9, GTPBP8, PUM3, ANK2, SLC12A7 REACT:R-HSA-1430728, REACT:R-HSA-611105
Medium
Neurologic Manifestations GSTM4, GRM6, FAM110C, ACAD9-DT, MRPL36 REACT:R-HSA-1430728, REACT:R-HSA-611105
Medium
Cranial Nerve Diseases GRM6, PUM3, LRPPRC, MROH2B, ANK2 REACT:R-HSA-611105
Medium
Spinal Cord Ischemia ACAD9-DT, LRPPRC, PHACTR2, SDHA, GRM6 REACT:R-HSA-76005
Medium
Autoimmune Disorders
Disease Associated Genes Pathways Predisposition
Connective Tissue Diseases ZDHHC11, ZNF518B, GSTM4, PUM3, GTPBP8 REACT:R-HSA-6805567, REACT:R-HSA-76002
Low
Immune System Diseases SLC12A7, ANK2, ZFYVE9, FOXD4, ACAD9-DT REACT:R-HSA-6805567, REACT:R-HSA-74160, REACT:R-HSA-76002
Medium
Autoimmune Diseases PUM3, ANK2, MRPL36, GSTM4, TMEM45A REACT:R-HSA-6805567, REACT:R-HSA-76002
Medium
Demyelinating Autoimmune Diseases, Cns PHACTR2, TMEM45A, FOXD4, MROH2B, ANK2 REACT:R-HSA-6805567
Low
Heart Health (Cardiovascular Diseases)
Disease Associated Genes Pathways Predisposition
Cardiovascular Abnormalities MROH2B, GTPBP8, SLC12A7, PHACTR2, LRPPRC REACT:R-HSA-6805567
Medium
Cardiomyopathy, Hypertrophic FOXD4, GSTM4, SDHA, TMEM45A, ZDHHC11 REACT:R-HSA-6805567
Medium
Vascular Diseases LRPPRC, ZNF518B, TMEM45A, GSTM4, PHACTR2 REACT:R-HSA-76002, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Hypertension ACAD9-DT, TMEM45A, GRM6, NQO2, ZNF518B REACT:R-HSA-76002, REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Coronary Artery Disease GTPBP8, SLC12A7, MRPL36, ZDHHC11, GSTM4 REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Dermatological Diseases
Disease Associated Genes Pathways Predisposition
Skin And Connective Tissue Diseases GTPBP8, LRPPRC, ZFYVE9, SDHA, ZDHHC11 REACT:R-HSA-6805567, REACT:R-HSA-74160, REACT:R-HSA-1430728, REACT:R-HSA-76002, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Endocrine Disorders
Disease Associated Genes Pathways Predisposition
Endocrine System Diseases SLC12A7, ZNF518B, PUM3, MRPL36, FOXD4 REACT:R-HSA-74160
Medium
Gastrointestinal Disorders
Disease Associated Genes Pathways Predisposition
Digestive System Diseases GTPBP8, ACAD9-DT, GRM6, MRPL36, FOXD4 REACT:R-HSA-74160, REACT:R-HSA-76002
Medium
Gastrointestinal Diseases LRPPRC, FOXD4, GTPBP8, SDHA, MRPL36 REACT:R-HSA-74160, REACT:R-HSA-76002
Medium
Intestinal Diseases FOXD4, GTPBP8, ZDHHC11, ZNF518B, MRPL36 REACT:R-HSA-74160, REACT:R-HSA-76002
Medium
Genitourinary Disorders
Disease Associated Genes Pathways Predisposition
Male Urogenital Diseases ANK2, FOXD4, ZNF518B, GSTM4, MRPL36 REACT:R-HSA-74160, REACT:R-HSA-1430728
Medium
Hematological Disorders
Disease Associated Genes Pathways Predisposition
Hemic And Lymphatic Diseases ZDHHC11, ACAD9-DT, SDHA, MRPL36, TMEM45A REACT:R-HSA-74160, REACT:R-HSA-76002, REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Hematologic Diseases ACTN2, TMEM45A, FAM110C, ACAD9, NQO2 REACT:R-HSA-76002, REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Blood Coagulation Disorders ZNF518B, FOXD4, GTPBP8, MRPL36, ACTN2 REACT:R-HSA-76002, REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Hemorrhagic Disorders GTPBP8, PHACTR2, ACAD9-DT, SDHA, ZNF518B REACT:R-HSA-76002, REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Thrombophilia SLC12A7, GRM6, ZFYVE9, ZNF518B, GSTM4 REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Metabolic Disorders
Disease Associated Genes Pathways Predisposition
Carbohydrate Metabolism, Inborn Errors MROH2B, ACAD9, SLC12A7, GSTM4, ACTN2 REACT:R-HSA-1430728, REACT:R-HSA-611105
Medium
Lipid Metabolism Disorders ZNF518B, FOXD4, GSTM4, SDHA, TMEM45A REACT:R-HSA-1430728
Medium
Lipidoses FAM110C, SDHA, MROH2B, SLC12A7, ZNF518B REACT:R-HSA-1430728
Medium
Obesity ZNF518B, ZFYVE9, GRM6, GTPBP8, FOXD4 REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Diabetes Mellitus, Type 1 GRM6, PHACTR2, ACTN2, PUM3, ZDHHC11 REACT:R-HSA-114608
Medium
Lipid Metabolism, Inborn Errors MROH2B, ACTN2, ACAD9, ZDHHC11, ACAD9-DT REACT:R-HSA-1430728, REACT:R-HSA-611105, REACT:R-HSA-114608, REACT:R-HSA-76005
Medium
Musculoskeletal Diseases
Disease Associated Genes Pathways Predisposition
Musculoskeletal Diseases MRPL36, ANK2, ACTN2, SDHA, GTPBP8 REACT:R-HSA-74160, REACT:R-HSA-1430728, REACT:R-HSA-76002, REACT:R-HSA-611105
Medium
Muscular Diseases SDHA, ZFYVE9, SLC12A7, PHACTR2, TMEM45A REACT:R-HSA-611105
Medium
Cancers (Neoplastic Diseases)
Disease Associated Genes Pathways Predisposition
Genital Neoplasms, Male ZFYVE9, ACAD9, ZDHHC11, MRPL36, NQO2 REACT:R-HSA-6805567
Medium
Prostatic Neoplasms ZDHHC11, TMEM45A, LRPPRC, ZFYVE9, SLC12A7 REACT:R-HSA-6805567
Medium
Breast Neoplasms FAM110C, SDHA, LRPPRC, ACAD9-DT, GRM6 REACT:R-HSA-74160
Medium
Gastrointestinal Neoplasms SDHA, MRPL36, GSTM4, MROH2B, ACAD9 REACT:R-HSA-74160
Medium
Digestive System Neoplasms FAM110C, ANK2, LRPPRC, ACTN2, PHACTR2 REACT:R-HSA-74160
Medium
Obstetric and Gynecological Disorders
Disease Associated Genes Pathways Predisposition
Female Urogenital Diseases And Pregnancy Complications TMEM45A, ACAD9, SDHA, GRM6, PHACTR2 REACT:R-HSA-74160
Medium
Ophthalmological Diseases
Disease Associated Genes Pathways Predisposition
Eye Diseases, Hereditary SDHA, ACAD9-DT, NQO2, ZFYVE9, ANK2 REACT:R-HSA-611105
Medium
Mendelian Disorders

Based on our analysis of your DNA exome, we did not predict any Ophthalmological diseases.

High Predisposition

Alzheimer's disease is a neurodegenerative disorder.

Your Relationship with Alzheimer Disease

Healthcare Professionals

Associated Genes:

Learn more about Alzheimer Disease
Medium Predisposition

Central nervous system (CNS) diseases encompass a wide range of conditions that affect the brain and spinal cord.

Your Relationship with Nervous System Diseases

Healthcare Professionals

Associated Genes:

Learn more about Central Nervous System Disease
Medium Predisposition

Neurodegenerative disorders can vary widely in their type and genetic transmission.

Your Relationship with Neurodegenerative Diseases

Healthcare Professionals

Associated Genes:

Learn more about Neurodegenerative Disorder
Medium Predisposition

Cerebrovascular disease primarily includes conditions such as stroke, aneurysms, and arteriosclerosis affecting the blood vessels in the brain.

Your Relationship with Cerebrovascular Disorders

Healthcare Professionals

Associated Genes:

Learn more about Cerebrovascular Disease
Medium Predisposition

Central nervous system (CNS) diseases encompass a wide range of conditions that affect the brain and spinal cord.

Your Relationship with central nervous system diseases

Healthcare Professionals

Associated Genes:

Learn more about Central Nervous System Disease
Medium Predisposition

Diseases of metabolism can include various conditions such as metabolic disorders or inborn errors of metabolism.

Your Relationship with brain diseases, metabolic

Healthcare Professionals

Associated Genes:

Learn more about Disease Of Metabolism
Medium Predisposition

The type of genetic transmission for neuromuscular diseases can vary significantly depending on the specific disease in question.

Your Relationship with neuromuscular diseases

Healthcare Professionals

Associated Genes:

Learn more about Neuromuscular Disease
Medium Predisposition

Lysosomal storage diseases (LSDs) are a group of inherited metabolic disorders characterized by an abnormal build-up of various toxic materials in the body's cells due to enzyme deficiencies.

Your Relationship with lysosomal storage diseases, nervous system

Healthcare Professionals

Associated Genes:

Learn more about Lysosomal Storage Disease
Medium Predisposition

Lice infestation is caused by an external parasite and is not genetically transmitted.

Your Relationship with neurologic manifestations

Healthcare Professionals

Associated Genes:

Learn more about Lice Infestation
Medium Predisposition

Cranial nerve diseases encompass a variety of conditions that affect the cranial nerves.

Your Relationship with cranial nerve diseases

Healthcare Professionals

Associated Genes:

Learn more about Cranial Nerve Disease
Medium Predisposition

Spinal cord disorders can vary widely, and their type and genetic transmission depend on the specific disorder.

Your Relationship with Spinal Cord Ischemia

Healthcare Professionals

Associated Genes:

Learn more about Spinal Cord Disorder
Low Predisposition

Mixed connective tissue disease is an autoimmune disorder.

Your Relationship with Connective Tissue Diseases

Healthcare Professionals

Associated Genes:

Learn more about Mixed Connective Tissue Disease
Medium Predisposition

Immune system diseases can broadly be categorized into two types: autoimmune diseases and immunodeficiency diseases.

Your Relationship with immune system diseases

Healthcare Professionals

Associated Genes:

Learn more about Immune System Disease
Medium Predisposition

Uterine diseases encompass various conditions, including: 1.

Your Relationship with Autoimmune Diseases

Healthcare Professionals

Associated Genes:

Learn more about Uterine Disease
Low Predisposition

Demyelinating diseases generally refer to a group of disorders characterized by damage to the myelin sheath of neurons.

Your Relationship with demyelinating autoimmune diseases, cns

Healthcare Professionals

Associated Genes:

Learn more about Demyelinating Disease
Medium Predisposition

Cardiovascular phenotypes can refer to a range of physical characteristics or conditions related to the heart and blood vessels.

Your Relationship with Cardiovascular Abnormalities

Healthcare Professionals

Associated Genes:

Learn more about Cardiovascular Phenotype
Medium Predisposition

Cardiomyopathy can generally be categorized into a few primary types: 1.

Your Relationship with Cardiomyopathy, Hypertrophic

Healthcare Professionals

Associated Genes:

Learn more about Cardiomyopathy
Medium Predisposition

Vascular diseases are typically not classified as a single type since they include various conditions that affect the blood vessels.

Your Relationship with Vascular Diseases

Healthcare Professionals

Associated Genes:

Learn more about Vascular Disease
Medium Predisposition

Hypertension, or high blood pressure, is typically categorized into two types: primary (essential) hypertension and secondary hypertension.

Your Relationship with Hypertension

Healthcare Professionals

Associated Genes:

Learn more about Hypertension
Medium Predisposition

Coronary artery disease (CAD) is a multifactorial disease, meaning it results from a combination of genetic and environmental factors.

Your Relationship with Coronary Artery Disease

Healthcare Professionals

Associated Genes:

Learn more about Coronary Artery Disease
Medium Predisposition

Mixed connective tissue disease is an autoimmune disorder.

Your Relationship with skin and connective tissue diseases

Healthcare Professionals

Associated Genes:

Learn more about Mixed Connective Tissue Disease
Medium Predisposition

Immune system diseases can broadly be categorized into two types: autoimmune diseases and immunodeficiency diseases.

Your Relationship with Endocrine System Diseases

Healthcare Professionals

Associated Genes:

Learn more about Immune System Disease
Medium Predisposition

Auditory system diseases can vary widely in their genetic transmission.

Your Relationship with digestive system diseases

Healthcare Professionals

Associated Genes:

Learn more about Auditory System Disease
Medium Predisposition

The type of genetic transmission for gastrointestinal system diseases can vary based on the specific condition.

Your Relationship with Gastrointestinal Diseases

Healthcare Professionals

Associated Genes:

Learn more about Gastrointestinal System Disease
Medium Predisposition

Intestinal diseases can be broadly classified into various types, including infectious (e.

Your Relationship with Intestinal Diseases

Healthcare Professionals

Associated Genes:

Learn more about Intestinal Disease
Medium Predisposition

Periodontal disease does not follow a specific pattern of genetic transmission.

Your Relationship with Male Urogenital Diseases

Healthcare Professionals

Associated Genes:

Learn more about Periodontal Disease
Medium Predisposition

Lymphatic system diseases can include a variety of conditions such as lymphedema, lymphangitis, and lymphatic malformations.

Your Relationship with hemic and lymphatic diseases

Healthcare Professionals

Associated Genes:

Learn more about Lymphatic System Disease
Medium Predisposition

Hemoglobin C disease is a genetic blood disorder.

Your Relationship with Hematologic Diseases

Healthcare Professionals

Associated Genes:

Learn more about Hemoglobin C Disease
Medium Predisposition

Blood coagulation diseases can be classified into several types, such as hemophilia, von Willebrand disease, and thrombophilia.

Your Relationship with Blood Coagulation Disorders

Healthcare Professionals

Associated Genes:

Learn more about Blood Coagulation Disease
Medium Predisposition

Haemorrhagic disorders can be broadly classified into several types, including hemophilia, von Willebrand disease, and platelet function disorders.

Your Relationship with Hemorrhagic Disorders

Healthcare Professionals

Associated Genes:

Learn more about Haemorrhagic Disorder
Medium Predisposition

Thrombophilia is typically an inherited or acquired propensity to develop blood clots due to abnormalities in coagulation.

Your Relationship with Thrombophilia

Healthcare Professionals

Associated Genes:

Learn more about Thrombophilia
Medium Predisposition

Type of carbohydrate metabolic disorder: Several, including but not limited to: 1.

Your Relationship with carbohydrate metabolism, inborn errors

Healthcare Professionals

Associated Genes:

Learn more about Carbohydrate Metabolic Disorder
Medium Predisposition

Lipid metabolism disorders can be of various types, including: 1.

Your Relationship with lipid metabolism disorders

Healthcare Professionals

Associated Genes:

Learn more about Lipid Metabolism Disorder
Medium Predisposition

Mucolipidosis is classified into several types (I, II, III, and IV) based on the specific enzyme deficiency and clinical presentation.

Your Relationship with lipidoses

Healthcare Professionals

Associated Genes:

Learn more about Mucolipidosis
Medium Predisposition

Obesity can have a multifactorial genetic transmission.

Your Relationship with Obesity

Healthcare Professionals

Associated Genes:

Learn more about Obesity
Medium Predisposition

Diabetes mellitus includes several types, primarily Type 1 diabetes and Type 2 diabetes.

Your Relationship with Diabetes Mellitus, Type 1

Healthcare Professionals

Associated Genes:

Learn more about Diabetes Mellitus
Medium Predisposition

Lipid metabolism disorders can be of various types, including: 1.

Your Relationship with Lipid Metabolism, Inborn Errors

Healthcare Professionals

Associated Genes:

Learn more about Lipid Metabolism Disorder
Medium Predisposition

Musculoskeletal disorders are primarily non-genetic in nature, as they often result from lifestyle factors, repetitive motion, injuries, or age-related wear and tear.

Your Relationship with musculoskeletal diseases

Healthcare Professionals

Associated Genes:

Learn more about Musculoskeletal Disorder
Medium Predisposition

The type of genetic transmission for neuromuscular diseases can vary significantly depending on the specific disease in question.

Your Relationship with Muscular Diseases

Healthcare Professionals

Associated Genes:

Learn more about Neuromuscular Disease
Medium Predisposition

Meningeal neoplasms are a type of tumor that occurs in the meninges, which are the protective membranes covering the brain and spinal cord.

Your Relationship with genital neoplasms, male

Healthcare Professionals

Associated Genes:

Learn more about Meningeal Neoplasm
Medium Predisposition

Trophoblastic neoplasm is a type of gestational trophoblastic disease (GTD) that arises from abnormal growth of trophoblastic cells, which are cells that normally develop into the placenta during pregnancy.

Your Relationship with Prostatic Neoplasms

Healthcare Professionals

Associated Genes:

Learn more about Trophoblastic Neoplasm
Medium Predisposition

Breast neoplasm, often referred to as breast cancer, primarily manifests in two forms: invasive and non-invasive.

Your Relationship with Breast Neoplasms

Healthcare Professionals

Associated Genes:

Learn more about Breast Neoplasm
Medium Predisposition

Gastrointestinal anthrax is an infectious disease caused by the bacterium Bacillus anthracis.

Your Relationship with Gastrointestinal Neoplasms

Healthcare Professionals

Associated Genes:

Learn more about Gastrointestinal Anthrax
Medium Predisposition

Connective tissue benign neoplasms typically include types such as lipomas, fibromas, hemangiomas, and neurofibromas.

Your Relationship with Digestive System Neoplasms

Healthcare Professionals

Associated Genes:

Learn more about Connective Tissue Benign Neoplasm
Medium Predisposition

ALG1-congenital disorder of glycosylation is an autosomal recessive disorder.

Your Relationship with female urogenital diseases and pregnancy complications

Healthcare Professionals

Associated Genes:

Learn more about Alg1-congenital Disorder Of Glycosylation
Medium Predisposition

Eye diseases encompass a wide range of conditions, but common types include: 1.

Your Relationship with Eye Diseases, Hereditary

Healthcare Professionals

Associated Genes:

Learn more about Eye Disease