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Cancers (neoplastic Diseases)

Explore Genetic Insights

Summary

Diseases Found 46
High Risk 1
Medium Risk 43
Low Risk 2
Mutated Genes Found 21

Contents

Cancers (Neoplastic Diseases)

The following diseases are associated with Cancers (Neoplastic Diseases):

Disease Predisposition
Genital Neoplasms, Male Medium
Prostatic Neoplasms Medium
Breast Neoplasms Medium
Gastrointestinal Neoplasms Medium
Digestive System Neoplasms Medium

Genital Neoplasms, Male

Meningeal neoplasms are a type of tumor that occurs in the meninges, which are the protective membranes covering the brain and spinal cord. These tumors can be benign (such as meningiomas) or malignant. As for genetic transmission, most meningeal neoplasms, particularly sporadic meningiomas, are not typically inherited. However, there are genetic syndromes, such as Neurofibromatosis Type 2 (NF2), that significantly increase the risk of developing these types of tumors. NF2 is an autosomal dominant disorder, meaning that a mutation in a single copy of the responsible gene (NF2 gene on chromosome 22) can cause the condition.

Predisposition: Medium
Explanation of predisposition: We predict genetic risk by analyzing specific genetic variants within key genes associated with a condition. For each variant, we assess its impact on biological pathways that are known to influence the disease. The prediction takes into account both the clinical significance of each variant and the confidence in the prediction, which is determined by the quality and strength of the supporting scientific data and research.
Associated Genes
Gene Mutation Type Allele Confidence
ZFYVE9 Duplication G/C Medium
ACAD9 Duplication T/C Medium
ZDHHC11 Insertion C/T Medium
MRPL36 Deletion C/T Medium
NQO2 Frameshift C/T High
Population Frequency By Gene

Population frequency indicates how common a specific genetic variant is within a group of people, expressed as a percentage. For example, if a gene variant has a frequency of 20%, it means about 20 out of 100 individuals carry that variant. This information helps researchers understand the potential impact of genetic variants on health and traits within different populations.

Gene Frequency
ZFYVE9 7%
ACAD9 5%
ZDHHC11 7%
MRPL36 6%
NQO2 17%
Associated Pathways

A pathway refers to a series of biochemical reactions and interactions that occur within cells, allowing for communication between genes, proteins, and metabolites. These pathways are crucial for various physiological functions, including neurotransmission, hormone signaling, and metabolic processes, and can influence behaviors and health outcomes when disrupted by genetic mutations.

Pathway Type Effects
REACT:R-HSA-6805567 Wnt Signaling Pathway Modulates metabolism and energy use
Possible Comobordities

Comorbidities are additional health conditions that often occur alongside a primary condition. For example, someone with ADHD may also have other related issues, such as anxiety or learning difficulties. These conditions are linked because they may share similar causes, such as genetics or brain chemistry, making it more likely for a person to experience both at the same time.

Gene Comorbidities Associated Mechanism
ZFYVE9 Hypertension Immune system dysfunction
ACAD9 Hypertension Neurodegeneration
ZDHHC11 Stroke Neurodegeneration
MRPL36 Coronary Artery Disease Inflammation
NQO2 Osteoporosis Immune system dysfunction

Recommendations for Medium Risk for Meningeal Neoplasm

  • Consultation: Schedule a follow-up consultation with a primary care provider or genetic counselor.
  • Monitoring: Regularly monitor your health for early signs of the condition associated with your predisposition.
  • Lifestyle Adjustments: Implement moderate lifestyle changes to mitigate risk.
  • Personalized Lifestyle Plan:
    • Maintain a balanced diet rich in whole foods, lean protein, and healthy fats.
    • Engage in regular physical activity, such as walking, swimming, or light strength training.
    • Incorporate stress management techniques like deep breathing exercises or light yoga.
    • Limit alcohol consumption and reduce exposure to pollutants.

    For additional guidance on managing your predisposition: See treatment options for genital neoplasms, male.

Next Steps

Learn more about Meningeal Neoplasm.

See predicted treatments for genital neoplasms, male.

Schedule a consultation with a GeneHealth representative to discuss results.

Prostatic Neoplasms

Trophoblastic neoplasm is a type of gestational trophoblastic disease (GTD) that arises from abnormal growth of trophoblastic cells, which are cells that normally develop into the placenta during pregnancy. These neoplasms include conditions like hydatidiform mole, invasive mole, choriocarcinoma, and placental-site trophoblastic tumor. The type of genetic transmission for trophoblastic neoplasms is generally sporadic, meaning they are not inherited in a predictable pattern and typically occur due to genetic abnormalities during fertilization.

Predisposition: Medium
Explanation of predisposition: We predict genetic risk by analyzing specific genetic variants within key genes associated with a condition. For each variant, we assess its impact on biological pathways that are known to influence the disease. The prediction takes into account both the clinical significance of each variant and the confidence in the prediction, which is determined by the quality and strength of the supporting scientific data and research.
Associated Genes
Gene Mutation Type Allele Confidence
ZDHHC11 Substitution G/C High
TMEM45A Insertion T/T High
LRPPRC Deletion C/G High
ZFYVE9 Deletion G/T High
SLC12A7 Deletion A/C Medium
Population Frequency By Gene

Population frequency indicates how common a specific genetic variant is within a group of people, expressed as a percentage. For example, if a gene variant has a frequency of 20%, it means about 20 out of 100 individuals carry that variant. This information helps researchers understand the potential impact of genetic variants on health and traits within different populations.

Gene Frequency
ZDHHC11 22%
TMEM45A 19%
LRPPRC 8%
ZFYVE9 2%
SLC12A7 19%
Associated Pathways

A pathway refers to a series of biochemical reactions and interactions that occur within cells, allowing for communication between genes, proteins, and metabolites. These pathways are crucial for various physiological functions, including neurotransmission, hormone signaling, and metabolic processes, and can influence behaviors and health outcomes when disrupted by genetic mutations.

Pathway Type Effects
REACT:R-HSA-6805567 Dopaminergic Signaling Involved in cell growth and survival
Possible Comobordities

Comorbidities are additional health conditions that often occur alongside a primary condition. For example, someone with ADHD may also have other related issues, such as anxiety or learning difficulties. These conditions are linked because they may share similar causes, such as genetics or brain chemistry, making it more likely for a person to experience both at the same time.

Gene Comorbidities Associated Mechanism
ZDHHC11 Hypertension Oxidative stress
TMEM45A Osteoporosis Immune system dysfunction
LRPPRC Coronary Artery Disease Chronic infection
ZFYVE9 Osteoporosis Hormonal imbalance
SLC12A7 Diabetes Oxidative stress

Recommendations for Medium Risk for Trophoblastic Neoplasm

  • Consultation: Schedule a follow-up consultation with a primary care provider or genetic counselor.
  • Monitoring: Regularly monitor your health for early signs of the condition associated with your predisposition.
  • Lifestyle Adjustments: Implement moderate lifestyle changes to mitigate risk.
  • Personalized Lifestyle Plan:
    • Maintain a balanced diet rich in whole foods, lean protein, and healthy fats.
    • Engage in regular physical activity, such as walking, swimming, or light strength training.
    • Incorporate stress management techniques like deep breathing exercises or light yoga.
    • Limit alcohol consumption and reduce exposure to pollutants.

    For additional guidance on managing your predisposition: See treatment options for Prostatic Neoplasms.

Next Steps

Learn more about Trophoblastic Neoplasm.

See predicted treatments for Prostatic Neoplasms.

Schedule a consultation with a GeneHealth representative to discuss results.

Breast Neoplasms

Breast neoplasm, often referred to as breast cancer, primarily manifests in two forms: invasive and non-invasive. The type of genetic transmission associated with breast cancer can be hereditary or sporadic. Hereditary breast cancer often results from mutations in specific genes such as BRCA1 and BRCA2, which follow an autosomal dominant pattern of inheritance. This means a mutation in just one of the two copies of a gene is sufficient to increase the risk of developing the disease. Sporadic cases, which make up the majority, do not follow a specific pattern of inheritance and are typically attributed to genetic changes that occur by chance.

Predisposition: Medium
Explanation of predisposition: We predict genetic risk by analyzing specific genetic variants within key genes associated with a condition. For each variant, we assess its impact on biological pathways that are known to influence the disease. The prediction takes into account both the clinical significance of each variant and the confidence in the prediction, which is determined by the quality and strength of the supporting scientific data and research.
Associated Genes
Gene Mutation Type Allele Confidence
FAM110C Inversion T/T High
SDHA Insertion C/A Medium
LRPPRC Duplication A/A Medium
ACAD9-DT Substitution T/C High
GRM6 Substitution C/A Medium
Population Frequency By Gene

Population frequency indicates how common a specific genetic variant is within a group of people, expressed as a percentage. For example, if a gene variant has a frequency of 20%, it means about 20 out of 100 individuals carry that variant. This information helps researchers understand the potential impact of genetic variants on health and traits within different populations.

Gene Frequency
FAM110C 23%
SDHA 18%
LRPPRC 10%
ACAD9-DT 7%
GRM6 23%
Associated Pathways

A pathway refers to a series of biochemical reactions and interactions that occur within cells, allowing for communication between genes, proteins, and metabolites. These pathways are crucial for various physiological functions, including neurotransmission, hormone signaling, and metabolic processes, and can influence behaviors and health outcomes when disrupted by genetic mutations.

Pathway Type Effects
REACT:R-HSA-74160 Notch Signaling Pathway Impacts cellular stress response
Possible Comobordities

Comorbidities are additional health conditions that often occur alongside a primary condition. For example, someone with ADHD may also have other related issues, such as anxiety or learning difficulties. These conditions are linked because they may share similar causes, such as genetics or brain chemistry, making it more likely for a person to experience both at the same time.

Gene Comorbidities Associated Mechanism
FAM110C Cancer Genetic predisposition
SDHA Hypertension Oxidative stress
LRPPRC Cancer Neurodegeneration
ACAD9-DT Cancer Cellular apoptosis
GRM6 Asthma Chronic infection

Recommendations for Medium Risk for Breast Neoplasm

  • Consultation: Schedule a follow-up consultation with a primary care provider or genetic counselor.
  • Monitoring: Regularly monitor your health for early signs of the condition associated with your predisposition.
  • Lifestyle Adjustments: Implement moderate lifestyle changes to mitigate risk.
  • Personalized Lifestyle Plan:
    • Maintain a balanced diet rich in whole foods, lean protein, and healthy fats.
    • Engage in regular physical activity, such as walking, swimming, or light strength training.
    • Incorporate stress management techniques like deep breathing exercises or light yoga.
    • Limit alcohol consumption and reduce exposure to pollutants.

    For additional guidance on managing your predisposition: See treatment options for Breast Neoplasms.

Next Steps

Learn more about Breast Neoplasm.

See predicted treatments for Breast Neoplasms.

Schedule a consultation with a GeneHealth representative to discuss results.

Gastrointestinal Neoplasms

Gastrointestinal anthrax is an infectious disease caused by the bacterium Bacillus anthracis. It is not genetically transmitted; rather, it is acquired through the ingestion of undercooked or contaminated meat from infected animals.

Predisposition: Medium
Explanation of predisposition: We predict genetic risk by analyzing specific genetic variants within key genes associated with a condition. For each variant, we assess its impact on biological pathways that are known to influence the disease. The prediction takes into account both the clinical significance of each variant and the confidence in the prediction, which is determined by the quality and strength of the supporting scientific data and research.
Associated Genes
Gene Mutation Type Allele Confidence
SDHA Insertion A/T High
MRPL36 Duplication T/T Medium
GSTM4 Inversion G/A Medium
MROH2B Substitution C/C High
ACAD9 Frameshift T/G High
Population Frequency By Gene

Population frequency indicates how common a specific genetic variant is within a group of people, expressed as a percentage. For example, if a gene variant has a frequency of 20%, it means about 20 out of 100 individuals carry that variant. This information helps researchers understand the potential impact of genetic variants on health and traits within different populations.

Gene Frequency
SDHA 3%
MRPL36 18%
GSTM4 5%
MROH2B 17%
ACAD9 3%
Associated Pathways

A pathway refers to a series of biochemical reactions and interactions that occur within cells, allowing for communication between genes, proteins, and metabolites. These pathways are crucial for various physiological functions, including neurotransmission, hormone signaling, and metabolic processes, and can influence behaviors and health outcomes when disrupted by genetic mutations.

Pathway Type Effects
REACT:R-HSA-74160 Cholinergic Pathway Regulates neurotransmitter release
Possible Comobordities

Comorbidities are additional health conditions that often occur alongside a primary condition. For example, someone with ADHD may also have other related issues, such as anxiety or learning difficulties. These conditions are linked because they may share similar causes, such as genetics or brain chemistry, making it more likely for a person to experience both at the same time.

Gene Comorbidities Associated Mechanism
SDHA Coronary Artery Disease Inflammation
MRPL36 Stroke Oxidative stress
GSTM4 Chronic Obstructive Pulmonary Disease (COPD) Immune system dysfunction
MROH2B Cancer Cellular apoptosis
ACAD9 Cancer Inflammation

Recommendations for Medium Risk for Gastrointestinal Anthrax

  • Consultation: Schedule a follow-up consultation with a primary care provider or genetic counselor.
  • Monitoring: Regularly monitor your health for early signs of the condition associated with your predisposition.
  • Lifestyle Adjustments: Implement moderate lifestyle changes to mitigate risk.
  • Personalized Lifestyle Plan:
    • Maintain a balanced diet rich in whole foods, lean protein, and healthy fats.
    • Engage in regular physical activity, such as walking, swimming, or light strength training.
    • Incorporate stress management techniques like deep breathing exercises or light yoga.
    • Limit alcohol consumption and reduce exposure to pollutants.

    For additional guidance on managing your predisposition: See treatment options for Gastrointestinal Neoplasms.

Next Steps

Learn more about Gastrointestinal Anthrax.

See predicted treatments for Gastrointestinal Neoplasms.

Schedule a consultation with a GeneHealth representative to discuss results.

Digestive System Neoplasms

Connective tissue benign neoplasms typically include types such as lipomas, fibromas, hemangiomas, and neurofibromas. The genetic transmission of these neoplasms varies. Lipomas, for example, may have hereditary forms that follow an autosomal dominant pattern. Neurofibromas are commonly associated with neurofibromatosis type 1 (NF1), an autosomal dominant disorder. Transmission for other types like fibromas and hemangiomas may not be well-defined and could involve sporadic mutations or multifactorial inheritance.

Predisposition: Medium
Explanation of predisposition: We predict genetic risk by analyzing specific genetic variants within key genes associated with a condition. For each variant, we assess its impact on biological pathways that are known to influence the disease. The prediction takes into account both the clinical significance of each variant and the confidence in the prediction, which is determined by the quality and strength of the supporting scientific data and research.
Associated Genes
Gene Mutation Type Allele Confidence
FAM110C Deletion T/A Medium
ANK2 Substitution G/A High
LRPPRC Inversion T/G Medium
ACTN2 Frameshift C/A Medium
PHACTR2 Duplication G/G High
Population Frequency By Gene

Population frequency indicates how common a specific genetic variant is within a group of people, expressed as a percentage. For example, if a gene variant has a frequency of 20%, it means about 20 out of 100 individuals carry that variant. This information helps researchers understand the potential impact of genetic variants on health and traits within different populations.

Gene Frequency
FAM110C 5%
ANK2 1%
LRPPRC 11%
ACTN2 21%
PHACTR2 9%
Associated Pathways

A pathway refers to a series of biochemical reactions and interactions that occur within cells, allowing for communication between genes, proteins, and metabolites. These pathways are crucial for various physiological functions, including neurotransmission, hormone signaling, and metabolic processes, and can influence behaviors and health outcomes when disrupted by genetic mutations.

Pathway Type Effects
REACT:R-HSA-74160 Wnt Signaling Pathway Impacts cellular stress response
Possible Comobordities

Comorbidities are additional health conditions that often occur alongside a primary condition. For example, someone with ADHD may also have other related issues, such as anxiety or learning difficulties. These conditions are linked because they may share similar causes, such as genetics or brain chemistry, making it more likely for a person to experience both at the same time.

Gene Comorbidities Associated Mechanism
FAM110C Depression Inflammation
ANK2 Stroke Mitochondrial impairment
LRPPRC Asthma Immune system dysfunction
ACTN2 Chronic Obstructive Pulmonary Disease (COPD) Metabolic dysregulation
PHACTR2 Parkinson's Disease Neurodegeneration

Recommendations for Medium Risk for Connective Tissue Benign Neoplasm

  • Consultation: Schedule a follow-up consultation with a primary care provider or genetic counselor.
  • Monitoring: Regularly monitor your health for early signs of the condition associated with your predisposition.
  • Lifestyle Adjustments: Implement moderate lifestyle changes to mitigate risk.
  • Personalized Lifestyle Plan:
    • Maintain a balanced diet rich in whole foods, lean protein, and healthy fats.
    • Engage in regular physical activity, such as walking, swimming, or light strength training.
    • Incorporate stress management techniques like deep breathing exercises or light yoga.
    • Limit alcohol consumption and reduce exposure to pollutants.

    For additional guidance on managing your predisposition: See treatment options for Digestive System Neoplasms.

Next Steps

Learn more about Connective Tissue Benign Neoplasm.

See predicted treatments for Digestive System Neoplasms.

Schedule a consultation with a GeneHealth representative to discuss results.

Appendix

Mutated Genes Found

Diseases Found

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